Matches in SemOpenAlex for { <https://semopenalex.org/work/W588049506> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W588049506 abstract "Solid tumours are predisposed to hypoxic conditions due to cellular proliferation outpacing the rate of angiogenesis. Hypoxia is associated with enhanced tumour aggression. We aimed to study how hypoxia influences the migration and invasion of Neuroblastoma, a common and highly lethal, enigmatic childhood cancer. Fluorescently labelled Neuroblastoma cell lines were cultivated under atmospheric (‘normoxic’) or hypoxic conditions for 3 days before implantation upon the chorioallantoic membrane (CAM) of chick embryos and observed in-vivo for tumour formation and metastasis.Tumourigenesis was successful regardless of oxygen levels. Normoxic cells failed to metastasise, conversely hypoxic cells invaded the embryo forming tumour spheres in several organs. Interestingly, ‘normoxic’ cell invasion was observed when implanted alongside hypoxic cells resulting in co-invasion and independent microtumour deposition. These processes were later identified as ‘HIF dependent,’ following pretreatment of cells with DMOG.In conclusion we found an increase in metastatic phenotype following exposure to hypoxia via stabilisation of the HIF transcription factor. This CAM model was also utilised in order to begin to understand the molecular mechanisms underpinning the aggressive and erratic clinical behaviour of Neuroblastoma." @default.
- W588049506 created "2016-06-24" @default.
- W588049506 creator A5059811480 @default.
- W588049506 date "2000-01-01" @default.
- W588049506 modified "2023-09-24" @default.
- W588049506 title "The roles of hypoxia on neuroblastoma cell migration and invasion" @default.
- W588049506 hasPublicationYear "2000" @default.
- W588049506 type Work @default.
- W588049506 sameAs 588049506 @default.
- W588049506 citedByCount "0" @default.
- W588049506 crossrefType "journal-article" @default.
- W588049506 hasAuthorship W588049506A5059811480 @default.
- W588049506 hasConcept C121608353 @default.
- W588049506 hasConcept C142724271 @default.
- W588049506 hasConcept C1491633281 @default.
- W588049506 hasConcept C178790620 @default.
- W588049506 hasConcept C185592680 @default.
- W588049506 hasConcept C196843134 @default.
- W588049506 hasConcept C207001950 @default.
- W588049506 hasConcept C2776715637 @default.
- W588049506 hasConcept C2779013556 @default.
- W588049506 hasConcept C2780394083 @default.
- W588049506 hasConcept C502942594 @default.
- W588049506 hasConcept C540031477 @default.
- W588049506 hasConcept C54355233 @default.
- W588049506 hasConcept C71924100 @default.
- W588049506 hasConcept C7836513 @default.
- W588049506 hasConcept C81885089 @default.
- W588049506 hasConcept C86803240 @default.
- W588049506 hasConcept C95444343 @default.
- W588049506 hasConcept C96232424 @default.
- W588049506 hasConcept C97230052 @default.
- W588049506 hasConceptScore W588049506C121608353 @default.
- W588049506 hasConceptScore W588049506C142724271 @default.
- W588049506 hasConceptScore W588049506C1491633281 @default.
- W588049506 hasConceptScore W588049506C178790620 @default.
- W588049506 hasConceptScore W588049506C185592680 @default.
- W588049506 hasConceptScore W588049506C196843134 @default.
- W588049506 hasConceptScore W588049506C207001950 @default.
- W588049506 hasConceptScore W588049506C2776715637 @default.
- W588049506 hasConceptScore W588049506C2779013556 @default.
- W588049506 hasConceptScore W588049506C2780394083 @default.
- W588049506 hasConceptScore W588049506C502942594 @default.
- W588049506 hasConceptScore W588049506C540031477 @default.
- W588049506 hasConceptScore W588049506C54355233 @default.
- W588049506 hasConceptScore W588049506C71924100 @default.
- W588049506 hasConceptScore W588049506C7836513 @default.
- W588049506 hasConceptScore W588049506C81885089 @default.
- W588049506 hasConceptScore W588049506C86803240 @default.
- W588049506 hasConceptScore W588049506C95444343 @default.
- W588049506 hasConceptScore W588049506C96232424 @default.
- W588049506 hasConceptScore W588049506C97230052 @default.
- W588049506 hasLocation W5880495061 @default.
- W588049506 hasOpenAccess W588049506 @default.
- W588049506 hasPrimaryLocation W5880495061 @default.
- W588049506 hasRelatedWork W1980006020 @default.
- W588049506 hasRelatedWork W2008634225 @default.
- W588049506 hasRelatedWork W2038021914 @default.
- W588049506 hasRelatedWork W2047229291 @default.
- W588049506 hasRelatedWork W2066974925 @default.
- W588049506 hasRelatedWork W2069642447 @default.
- W588049506 hasRelatedWork W2081124475 @default.
- W588049506 hasRelatedWork W2132291337 @default.
- W588049506 hasRelatedWork W2134641840 @default.
- W588049506 hasRelatedWork W2148128212 @default.
- W588049506 hasRelatedWork W2219527824 @default.
- W588049506 hasRelatedWork W2377984276 @default.
- W588049506 hasRelatedWork W2567257391 @default.
- W588049506 hasRelatedWork W2615867930 @default.
- W588049506 hasRelatedWork W2739554834 @default.
- W588049506 hasRelatedWork W2903694002 @default.
- W588049506 hasRelatedWork W3001569083 @default.
- W588049506 hasRelatedWork W3088056399 @default.
- W588049506 hasRelatedWork W1638946694 @default.
- W588049506 hasRelatedWork W2552942010 @default.
- W588049506 isParatext "false" @default.
- W588049506 isRetracted "false" @default.
- W588049506 magId "588049506" @default.
- W588049506 workType "article" @default.