Matches in SemOpenAlex for { <https://semopenalex.org/work/W58813214> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W58813214 endingPage "2559" @default.
- W58813214 startingPage "2551" @default.
- W58813214 abstract "The spontaneous activity of locus coeruleus (LC) noradrenergic neurons was assessed by single unit recording in adult recovered rats undernourished at perinatal age as compared with wellnourished animals. Locus coeruleus activity, measured by the firing rate of noradrenergic neurons and the number of spontaneously active cells/track was significantly higher in deprived rats than in controls. In addition, dose-response curves for the inhibitory LC activity of clonidine showed a shift to the right in deprived animals indicating a subsensitivity of alpha2-adrenergic autoreceptors. This fact suggests an alteration in the negative feedback mechanism mediated by somatodentritic alpha2 autoreceptors that modulate the activity of LC neurons, and may account for the behavioral alterations attributed to early undernutrition. Repeated desipramine (DMI) administration to deprived rats reduced LC activity to values comparable to controls, which were not affected after a similar treatment. These data extend to previous reports on long-lasting or permanent plastic changes in the CNS induced by early undernutrition, which may be reverted by pharmacological manipulations. In addition, these results support the hypothesis that alterations induced by early undernutrition are in the same direction as and resemble those described for patients with panic disorders. Furthermore, together with behavioral alterations and selective anxiolytic effect of DMI and other drugs with antipanic effects described in early malnourished rats, the present data support the proposal that perinatally deprived rats may be a useful model for screening drugs with potential antipanic activity." @default.
- W58813214 created "2016-06-24" @default.
- W58813214 creator A5001792938 @default.
- W58813214 creator A5048447370 @default.
- W58813214 creator A5057072984 @default.
- W58813214 creator A5041000120 @default.
- W58813214 date "2001-10-01" @default.
- W58813214 modified "2023-10-10" @default.
- W58813214 title "Increased neuronal activity in locus coeruleus from adult rats undernourished at perinatal age" @default.
- W58813214 doi "https://doi.org/10.1016/s0024-3205(01)01335-2" @default.
- W58813214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11693262" @default.
- W58813214 hasPublicationYear "2001" @default.
- W58813214 type Work @default.
- W58813214 sameAs 58813214 @default.
- W58813214 citedByCount "11" @default.
- W58813214 countsByYear W588132142019 @default.
- W58813214 countsByYear W588132142021 @default.
- W58813214 countsByYear W588132142022 @default.
- W58813214 crossrefType "journal-article" @default.
- W58813214 hasAuthorship W58813214A5001792938 @default.
- W58813214 hasAuthorship W58813214A5041000120 @default.
- W58813214 hasAuthorship W58813214A5048447370 @default.
- W58813214 hasAuthorship W58813214A5057072984 @default.
- W58813214 hasConcept C118552586 @default.
- W58813214 hasConcept C126322002 @default.
- W58813214 hasConcept C134018914 @default.
- W58813214 hasConcept C169760540 @default.
- W58813214 hasConcept C170493617 @default.
- W58813214 hasConcept C2775864247 @default.
- W58813214 hasConcept C2777765862 @default.
- W58813214 hasConcept C2778399450 @default.
- W58813214 hasConcept C2778468602 @default.
- W58813214 hasConcept C2779177272 @default.
- W58813214 hasConcept C2779424989 @default.
- W58813214 hasConcept C2780250439 @default.
- W58813214 hasConcept C2780712732 @default.
- W58813214 hasConcept C2781161787 @default.
- W58813214 hasConcept C529278444 @default.
- W58813214 hasConcept C558461103 @default.
- W58813214 hasConcept C71924100 @default.
- W58813214 hasConcept C74254510 @default.
- W58813214 hasConcept C8439214 @default.
- W58813214 hasConcept C86803240 @default.
- W58813214 hasConceptScore W58813214C118552586 @default.
- W58813214 hasConceptScore W58813214C126322002 @default.
- W58813214 hasConceptScore W58813214C134018914 @default.
- W58813214 hasConceptScore W58813214C169760540 @default.
- W58813214 hasConceptScore W58813214C170493617 @default.
- W58813214 hasConceptScore W58813214C2775864247 @default.
- W58813214 hasConceptScore W58813214C2777765862 @default.
- W58813214 hasConceptScore W58813214C2778399450 @default.
- W58813214 hasConceptScore W58813214C2778468602 @default.
- W58813214 hasConceptScore W58813214C2779177272 @default.
- W58813214 hasConceptScore W58813214C2779424989 @default.
- W58813214 hasConceptScore W58813214C2780250439 @default.
- W58813214 hasConceptScore W58813214C2780712732 @default.
- W58813214 hasConceptScore W58813214C2781161787 @default.
- W58813214 hasConceptScore W58813214C529278444 @default.
- W58813214 hasConceptScore W58813214C558461103 @default.
- W58813214 hasConceptScore W58813214C71924100 @default.
- W58813214 hasConceptScore W58813214C74254510 @default.
- W58813214 hasConceptScore W58813214C8439214 @default.
- W58813214 hasConceptScore W58813214C86803240 @default.
- W58813214 hasIssue "21" @default.
- W58813214 hasLocation W588132141 @default.
- W58813214 hasLocation W588132142 @default.
- W58813214 hasOpenAccess W58813214 @default.
- W58813214 hasPrimaryLocation W588132141 @default.
- W58813214 hasRelatedWork W2015995364 @default.
- W58813214 hasRelatedWork W2040208665 @default.
- W58813214 hasRelatedWork W2044970634 @default.
- W58813214 hasRelatedWork W2057198179 @default.
- W58813214 hasRelatedWork W2062996561 @default.
- W58813214 hasRelatedWork W2072746679 @default.
- W58813214 hasRelatedWork W2093191371 @default.
- W58813214 hasRelatedWork W2348711571 @default.
- W58813214 hasRelatedWork W3148737105 @default.
- W58813214 hasRelatedWork W4244081455 @default.
- W58813214 hasVolume "69" @default.
- W58813214 isParatext "false" @default.
- W58813214 isRetracted "false" @default.
- W58813214 magId "58813214" @default.
- W58813214 workType "article" @default.