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- W588733124 abstract "Insulin resistance and hyperinsulinemia may play a role in the development of atherosclerosis. To clarify this, rats with transplanted pancreas and insulin substrate-1 (IRS-1) knockout mice were examined. Syngeneic pancreatico duodenal transplantation with systemic venous drainage was performed in Wistar Shionogi (WS) and Spontaneous Hypertensive Rat (SHR) rats. Blood insulin levels of transplanted group are 1.5 to 2.5-fold higher than non-transplanted group. They revealed increased accumulation of cholesterol ester in aorta and slight body weight gain but neither hypertriglycemia nor hypertension. After a targeted disruption of the IRS-1 gene locus, mice show insulin resistance. They revealed both increased systolic blood pressure and increased serum triglyceride. Our results indicate that insulin resistance is important for the development of hypertension and hypertriglycemia, and hyperinsulinemia contributes to the acceleration of cholesterol ester accumulation in aorta." @default.
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- W588733124 date "1997-01-01" @default.
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- W588733124 title "The Effect of Hyperinsulinemia and Insulin Resistance on Atherosclerosis in Rats with Transplanted Pancreas and In Insulin Receptor Substrate-1 (IRS-1) Knockout Mouse" @default.
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- W588733124 doi "https://doi.org/10.5551/jat1973.24.10_505" @default.
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