FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W5890223> ?p ?o ?g. }

• W5890223 endingPage "85" @default.
• W5890223 startingPage "273" @default.
• W5890223 abstract "Depression of one or more parameters of cellular and/or humoral immune responses was found in 60% of general hospital patients treated with phenytoin and 47% of patients treated with carbamazepine. Phenytoin-treated patients failed to manifest delayed hypersensitivity (DHS) reactions to common antigens, and to make antibody to Salmonella typhi and tetanus toxoid. Serum levels of IgA and IgM, DNA synthesis in circulating leucocytes, and phytohaemagglutinin (PHA) induced deoxyribonucleic acid synthesis were also low. Depression of IgA, DHS reactivity and antibody responsiveness to S. typhi were shown to develop after the commencement of phenytoin therapy in a study of eleven patients. The presence of immunological defects was independent of the dosage of drug, its serum concentration, the duration of therapy and the sex of the subject. Studies in vitro provided evidence that immunosuppression was the result of a direct effect of phenytoin on the metabolism of lymphoid cells. Carbamazepine was shown to have a similar but less potent direct effect. Pharmacological concentrations of phenytoin caused a significant depression of DNA synthesis in PHA-stimulated and non-stimulated blood cell cultures in vitro. High concentrations in addition caused depression of cell counts, lymphocyte blastogenesis, ribonucleic acid and protein synthesis. Phenytoin was not cytocidal at concentrations of up to 125 mug/ml. Depression of DNA synthesis by phenytoin was maximal when phenytoin was added within 4-8 hr of the addition of PHA. PHA-induced DNA synthesis was not significantly affected by pre-incubation with phenytoin. In vivo, the presence of immunological defects was not related to phenytoin-induced folic acid deficiency. High concentrations of carbamazepine, but not phenobarbitone or diazepam caused a significant depression of PHA-stimulated DNA synthesis in blood cell cultures. The data show that immunosuppression is a common side-effect of phenytoin therapy, and that lymphoma is rare. They suggest that in the presence of phenytoin-induced immunosuppression another factor, or factors are required to induce the formation of lymphoma." @default.
• W5890223 created "2016-06-24" @default.
• W5890223 creator A5003200091 @default.
• W5890223 creator A5022370216 @default.
• W5890223 date "1975-05-01" @default.
• W5890223 modified "2023-10-17" @default.
• W5890223 title "Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro." @default.
• W5890223 cites W1512152103 @default.
• W5890223 cites W154310501 @default.
• W5890223 cites W1841561326 @default.
• W5890223 cites W1943451672 @default.
• W5890223 cites W1972744745 @default.
• W5890223 cites W1982039936 @default.
• W5890223 cites W1995201350 @default.
• W5890223 cites W1998940604 @default.
• W5890223 cites W2002957328 @default.
• W5890223 cites W2006269196 @default.
• W5890223 cites W2028393074 @default.
• W5890223 cites W2041120612 @default.
• W5890223 cites W2056798605 @default.
• W5890223 cites W2069760069 @default.
• W5890223 cites W2083720086 @default.
• W5890223 cites W2088194200 @default.
• W5890223 cites W2407559635 @default.
• W5890223 cites W2410350015 @default.
• W5890223 cites W2410796411 @default.
• W5890223 cites W2417406902 @default.
• W5890223 cites W2419241729 @default.
• W5890223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1538200" @default.
• W5890223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1212810" @default.
• W5890223 hasPublicationYear "1975" @default.
• W5890223 type Work @default.
• W5890223 sameAs 5890223 @default.
• W5890223 citedByCount "47" @default.
• W5890223 countsByYear W58902232012 @default.
• W5890223 countsByYear W58902232014 @default.
• W5890223 countsByYear W58902232015 @default.
• W5890223 countsByYear W58902232020 @default.
• W5890223 countsByYear W58902232022 @default.
• W5890223 crossrefType "journal-article" @default.
• W5890223 hasAuthorship W5890223A5003200091 @default.
• W5890223 hasAuthorship W5890223A5022370216 @default.
• W5890223 hasConcept C118552586 @default.
• W5890223 hasConcept C126322002 @default.
• W5890223 hasConcept C150903083 @default.
• W5890223 hasConcept C159654299 @default.
• W5890223 hasConcept C202751555 @default.
• W5890223 hasConcept C203014093 @default.
• W5890223 hasConcept C207001950 @default.
• W5890223 hasConcept C2775858608 @default.
• W5890223 hasConcept C2777761686 @default.
• W5890223 hasConcept C2778186239 @default.
• W5890223 hasConcept C2778337148 @default.
• W5890223 hasConcept C2779253243 @default.
• W5890223 hasConcept C55493867 @default.
• W5890223 hasConcept C64241487 @default.
• W5890223 hasConcept C71924100 @default.
• W5890223 hasConcept C86803240 @default.
• W5890223 hasConcept C8891405 @default.
• W5890223 hasConcept C98274493 @default.
• W5890223 hasConceptScore W5890223C118552586 @default.
• W5890223 hasConceptScore W5890223C126322002 @default.
• W5890223 hasConceptScore W5890223C150903083 @default.
• W5890223 hasConceptScore W5890223C159654299 @default.
• W5890223 hasConceptScore W5890223C202751555 @default.
• W5890223 hasConceptScore W5890223C203014093 @default.
• W5890223 hasConceptScore W5890223C207001950 @default.
• W5890223 hasConceptScore W5890223C2775858608 @default.
• W5890223 hasConceptScore W5890223C2777761686 @default.
• W5890223 hasConceptScore W5890223C2778186239 @default.
• W5890223 hasConceptScore W5890223C2778337148 @default.
• W5890223 hasConceptScore W5890223C2779253243 @default.
• W5890223 hasConceptScore W5890223C55493867 @default.
• W5890223 hasConceptScore W5890223C64241487 @default.
• W5890223 hasConceptScore W5890223C71924100 @default.
• W5890223 hasConceptScore W5890223C86803240 @default.
• W5890223 hasConceptScore W5890223C8891405 @default.
• W5890223 hasConceptScore W5890223C98274493 @default.
• W5890223 hasIssue "2" @default.
• W5890223 hasLocation W58902231 @default.
• W5890223 hasOpenAccess W5890223 @default.
• W5890223 hasPrimaryLocation W58902231 @default.
• W5890223 hasRelatedWork W1967077129 @default.
• W5890223 hasRelatedWork W1972631630 @default.
• W5890223 hasRelatedWork W2020426939 @default.
• W5890223 hasRelatedWork W2072053288 @default.
• W5890223 hasRelatedWork W2153335219 @default.
• W5890223 hasRelatedWork W2162363706 @default.
• W5890223 hasRelatedWork W2429723649 @default.
• W5890223 hasRelatedWork W3098373555 @default.
• W5890223 hasRelatedWork W395358204 @default.
• W5890223 hasRelatedWork W4229063249 @default.
• W5890223 hasVolume "20" @default.
• W5890223 isParatext "false" @default.
• W5890223 isRetracted "false" @default.
• W5890223 magId "5890223" @default.
• W5890223 workType "article" @default.