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- W589034978 abstract "Les ostéonécroses des maxillaires chez des patients traités par bisphosphonates ont largement été décrites dans la littérature. Récemment, des cas ont également été rapportés sous denosumab. Leur prise en charge est similaire et basée sur la classification en quatre stades de l’American Association of Oral and Maxillofacial Surgeons (AAOMS). Le traitement doit être multidisciplinaire. Deux options sont possibles et à discuter en fonction des thérapeutiques associées, de l’état général du patient et de la possibilité de fenêtre thérapeutique au cours du traitement anticancéreux : conservateur (traitement médicamenteux et chirurgie conservatrice de type débridement superficiel) et chirurgical radical. Nous présentons une mise au point sur la prise en charge des ostéonécroses en l’illustrant par l’évolution favorable de deux cas de stade 2 traités de façon conservatrice jusqu’à cicatrisation complète.Bisphosphonate-related osteonecrosis of the jaw have been widely described. Denosumab has recently been associated to ONJ. Guidance to clinicians is based on criteria established by the American Association of Oral and Maxillofacial Surgeons (AAOMS). Treatment should be multidisciplinary. Two options are available and have to be discussed on the basis of associated therapeutic, patient's general state of health and possibility of therapeutic window during cancer treatment: conservative (medication and conservative surgery like superficial debridement) and extensive surgery. Therefore, we report an update about management strategies of osteonecrosis of the jaw and two cases of patients with a stage 2 osteonecrosis of the jaw only treated with mouth rinses, antibiotics and debridement and complete healing." @default.
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- W589034978 date "2015-04-01" @default.
- W589034978 modified "2023-10-16" @default.
- W589034978 title "Les biphosphonates, nouveaux agents anticancéreux ?" @default.
- W589034978 doi "https://doi.org/10.1016/j.bulcan.2015.02.010" @default.
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