FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W589042044> ?p ?o ?g. }

• W589042044 endingPage "15" @default.
• W589042044 startingPage "15" @default.
• W589042044 abstract "Purpose:: Visual evoked potentials (VEPs) are widely used to objectively assess visual system function in animal models of ophthalmological diseases. Although use of chronically implanted electrodes is common in longitudinal VEP studies using rodent models, reliability of recordings over time has not been assessed. We compared VEPs 1 and 7 days after electrode implantation in the adult mouse. We also examined stimulus-independent changes over time, by assessing electroencephalogram (EEG) power and approximate entropy of the EEG signal. Methods:: Stainless steel screws (600-μm diameter) were implanted into the skull overlying the right visual cortex and the orbitofrontal cortex of adult mice (C57Bl/6J, n = 7). Animals were reanesthetized 1 and 7 days after implantation to record VEP responses (flashed gratings) and EEG activity. Brain sections were stained for glial activation (GFAP) and cell death (TUNEL). Results:: Reliability analysis, using intraclass correlation coefficients, showed VEP recordings had high reliability within the same session, regardless of time after electrode implantation and peak latencies and approximate entropy of the EEG did not change significantly with time. However, there was poorer reliability between recordings obtained on different days, and a significant decrease in VEP amplitudes and EEG power. This amplitude decrease could be normalized by scaling to EEG power (within-subjects). Furthermore, glial activation was present at both time points but there was no evidence of cell death. Conclusions:: These results indicate that VEP responses can be reliably recorded even after a relatively short recovery period but decrease response peak amplitude over time. Although scaling the VEP trace to EEG power normalized this decrease, our results highlight that time-dependent cortical excitability changes are an important consideration in longitudinal VEP studies. Translational Relevance:: This study shows changes in VEP characteristics over time in chronically implanted mice. Thus, future preclinical longitudinal studies should consider time in addition to amplitude and latency when designing and interpreting research." @default.
• W589042044 created "2016-06-24" @default.
• W589042044 creator A5007846768 @default.
• W589042044 creator A5020938172 @default.
• W589042044 creator A5053949360 @default.
• W589042044 creator A5065680357 @default.
• W589042044 creator A5073656496 @default.
• W589042044 date "2015-04-28" @default.
• W589042044 modified "2023-10-16" @default.
• W589042044 title "Reliability of VEP Recordings Using Chronically Implanted Screw Electrodes in Mice" @default.
• W589042044 cites W1481800006 @default.
• W589042044 cites W18226073 @default.
• W589042044 cites W1872625178 @default.
• W589042044 cites W1983689673 @default.
• W589042044 cites W1986900805 @default.
• W589042044 cites W1993480869 @default.
• W589042044 cites W1994681591 @default.
• W589042044 cites W2001477745 @default.
• W589042044 cites W2012796647 @default.
• W589042044 cites W2014828258 @default.
• W589042044 cites W2014922030 @default.
• W589042044 cites W2017105854 @default.
• W589042044 cites W2023299366 @default.
• W589042044 cites W2026206739 @default.
• W589042044 cites W2029207368 @default.
• W589042044 cites W2035763969 @default.
• W589042044 cites W2037698344 @default.
• W589042044 cites W2040709031 @default.
• W589042044 cites W2041997485 @default.
• W589042044 cites W2043043281 @default.
• W589042044 cites W2055749061 @default.
• W589042044 cites W2071171792 @default.
• W589042044 cites W2073140920 @default.
• W589042044 cites W2075199405 @default.
• W589042044 cites W2077204677 @default.
• W589042044 cites W2087002624 @default.
• W589042044 cites W2088314933 @default.
• W589042044 cites W2095674816 @default.
• W589042044 cites W2099114953 @default.
• W589042044 cites W2111736228 @default.
• W589042044 cites W2138956975 @default.
• W589042044 cites W2149858533 @default.
• W589042044 cites W2165745433 @default.
• W589042044 cites W2168760079 @default.
• W589042044 cites W2283094207 @default.
• W589042044 cites W24021922 @default.
• W589042044 doi "https://doi.org/10.1167/tvst.4.2.15" @default.
• W589042044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4413925" @default.
• W589042044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25938003" @default.
• W589042044 hasPublicationYear "2015" @default.
• W589042044 type Work @default.
• W589042044 sameAs 589042044 @default.
• W589042044 citedByCount "20" @default.
• W589042044 countsByYear W5890420442016 @default.
• W589042044 countsByYear W5890420442017 @default.
• W589042044 countsByYear W5890420442018 @default.
• W589042044 countsByYear W5890420442019 @default.
• W589042044 countsByYear W5890420442020 @default.
• W589042044 countsByYear W5890420442021 @default.
• W589042044 countsByYear W5890420442022 @default.
• W589042044 countsByYear W5890420442023 @default.
• W589042044 crossrefType "journal-article" @default.
• W589042044 hasAuthorship W589042044A5007846768 @default.
• W589042044 hasAuthorship W589042044A5020938172 @default.
• W589042044 hasAuthorship W589042044A5053949360 @default.
• W589042044 hasAuthorship W589042044A5065680357 @default.
• W589042044 hasAuthorship W589042044A5073656496 @default.
• W589042044 hasBestOaLocation W5890420442 @default.
• W589042044 hasConcept C104709138 @default.
• W589042044 hasConcept C136229726 @default.
• W589042044 hasConcept C15744967 @default.
• W589042044 hasConcept C169760540 @default.
• W589042044 hasConcept C185263204 @default.
• W589042044 hasConcept C185592680 @default.
• W589042044 hasConcept C2778823896 @default.
• W589042044 hasConcept C2779345533 @default.
• W589042044 hasConcept C2779918689 @default.
• W589042044 hasConcept C43617362 @default.
• W589042044 hasConcept C522805319 @default.
• W589042044 hasConcept C542102704 @default.
• W589042044 hasConcept C548259974 @default.
• W589042044 hasConcept C71924100 @default.
• W589042044 hasConcept C9893847 @default.
• W589042044 hasConceptScore W589042044C104709138 @default.
• W589042044 hasConceptScore W589042044C136229726 @default.
• W589042044 hasConceptScore W589042044C15744967 @default.
• W589042044 hasConceptScore W589042044C169760540 @default.
• W589042044 hasConceptScore W589042044C185263204 @default.
• W589042044 hasConceptScore W589042044C185592680 @default.
• W589042044 hasConceptScore W589042044C2778823896 @default.
• W589042044 hasConceptScore W589042044C2779345533 @default.
• W589042044 hasConceptScore W589042044C2779918689 @default.
• W589042044 hasConceptScore W589042044C43617362 @default.
• W589042044 hasConceptScore W589042044C522805319 @default.
• W589042044 hasConceptScore W589042044C542102704 @default.
• W589042044 hasConceptScore W589042044C548259974 @default.
• W589042044 hasConceptScore W589042044C71924100 @default.
• W589042044 hasConceptScore W589042044C9893847 @default.

• next