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- W5891123 abstract "Alzheimer's disease (AD) likely stems from many mechanisms, two of which are oxidative stress and inflammation. Lutein, an antioxidant, and DHA, an anti-inflammatory fatty acid, are preferentially stored in neural tissue and are positively associated with cognition. While DHA decreases neuroinflammation, lutein prevents oxidation of DHA. DHA may also increase lutein in the brain by modulating levels of HDL, a main transporter of lutein. Therefore, the aim of this study was to determine if a synergistic relationship exists between brain levels of lutein and DHA and cognition. Sixteen cognitive tests were completed pre-mortem by subjects from the Georgia Centenarian Study. Brain tissues from 48 decedents were analyzed for carotenoids and fatty acids using HPLC and GC, respectively. Regression analysis revealed a significant, non-synergistic lutein/DHA interaction for 5 cognitive tests, 4 of which are from the Consortium to Establish a Registry for AD test battery. Eight significant interactions were found between the temporal and frontal cortices (P<.05). The results indicate that the association of lutein or DHA with cognition is dependent on the other; however, their combined effect is less than expected if added together. Mechanistic studies on lutein and DHA are needed to further characterize the relationship between these two nutrients. Support: NIH 1PO1AG1755, DSM, Abbott Nutrition, USDA (5819500014)." @default.
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- W5891123 date "2013-04-01" @default.
- W5891123 modified "2023-10-17" @default.
- W5891123 title "The Relationship of Lutein and DHA in Cognitive Function" @default.
- W5891123 doi "https://doi.org/10.1096/fasebj.27.1_supplement.638.18" @default.
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