Matches in SemOpenAlex for { <https://semopenalex.org/work/W58957050> ?p ?o ?g. }
- W58957050 abstract "Since the discovery of olfactory dysfunction in Parkinson’s disease (PD) and Alzheimer’sdisease (AD) just over three decades ago, research into olfactory dysfunction in PD and ADhas grown vastly. It appeared that olfactory dysfunction is similar in PD and AD. However,recent studies show that the severity of olfactory dysfunction differs between PD and AD.Olfactory dysfunction in PD appears to be stable during disease progression and severityexcept for odour discrimination. In AD however, olfactory dysfunction in identification,discrimination and threshold is associated with severity and the degree of dementia. It hasbeen found that both PD an AD are preceded at approximately five years by olfactorydysfunction before the presence of typical symptoms. Typical symptoms for PD arebradykinesia, rest tremor and rigidity. For AD typical symptoms are cognitive impairment andmemory deficits. Also, olfactory dysfunction can identify future PD or AD developers froman at risk group. However, the predictive value of olfactory dysfunction in a generalpopulation is unknown.Another difference can be found in treatment response. Olfactory dysfunction improves inAD with acetylcholinesterase inhibitors (ChEI), where in PD, olfaction is unaffected bytypical dopaminergic treatment. There are a number of explanations for this difference,among which is that the underlying mechanism in PD is more complex and comprisesmultiple system, e.g. dopaminergic system and acetylcholinesterase (AChE) activity. It hasrecently been suggested that the AChE is more important in olfactory dysfunction in PD thanthe dopaminergic system.Olfactory testing appears very useful in early detection and differential diagnosis andcould be very useful in clinical settings, but further research is needed to investigate theunderlying mechanisms and possibilities for inclusion in treatment. Also, further researchcould focus on the link between movement and olfaction as seen in animals. Another possibleline of research is that of olfaction and emotion or lack thereof as seen in both PD and AD." @default.
- W58957050 created "2016-06-24" @default.
- W58957050 creator A5016338164 @default.
- W58957050 date "2010-10-21" @default.
- W58957050 modified "2023-09-27" @default.
- W58957050 title "Anosmia in Neurodegenerative disorders" @default.
- W58957050 cites W1490756559 @default.
- W58957050 cites W1523233088 @default.
- W58957050 cites W1547653356 @default.
- W58957050 cites W1966704731 @default.
- W58957050 cites W1970033499 @default.
- W58957050 cites W1980260502 @default.
- W58957050 cites W1983067887 @default.
- W58957050 cites W1984001875 @default.
- W58957050 cites W198549804 @default.
- W58957050 cites W1986152951 @default.
- W58957050 cites W1991462447 @default.
- W58957050 cites W1993940897 @default.
- W58957050 cites W1999686047 @default.
- W58957050 cites W1999721747 @default.
- W58957050 cites W2000058761 @default.
- W58957050 cites W2001229741 @default.
- W58957050 cites W2001537110 @default.
- W58957050 cites W2008119714 @default.
- W58957050 cites W2008560062 @default.
- W58957050 cites W2009128664 @default.
- W58957050 cites W2010082386 @default.
- W58957050 cites W2013044256 @default.
- W58957050 cites W2013504429 @default.
- W58957050 cites W2013801953 @default.
- W58957050 cites W2020101887 @default.
- W58957050 cites W2029232177 @default.
- W58957050 cites W2029948616 @default.
- W58957050 cites W2031164231 @default.
- W58957050 cites W2031603167 @default.
- W58957050 cites W2032085474 @default.
- W58957050 cites W2036425957 @default.
- W58957050 cites W2038819711 @default.
- W58957050 cites W2039992474 @default.
- W58957050 cites W2042668530 @default.
- W58957050 cites W2044400428 @default.
- W58957050 cites W2044470088 @default.
- W58957050 cites W2046023185 @default.
- W58957050 cites W2049067977 @default.
- W58957050 cites W2053258863 @default.
- W58957050 cites W2054709014 @default.
- W58957050 cites W2056569271 @default.
- W58957050 cites W2056749612 @default.
- W58957050 cites W2056795042 @default.
- W58957050 cites W2060756968 @default.
- W58957050 cites W2062964598 @default.
- W58957050 cites W2069130517 @default.
- W58957050 cites W2071655926 @default.
- W58957050 cites W2077248760 @default.
- W58957050 cites W2081608259 @default.
- W58957050 cites W2082369111 @default.
- W58957050 cites W2082503383 @default.
- W58957050 cites W2084490068 @default.
- W58957050 cites W2085329193 @default.
- W58957050 cites W2089504946 @default.
- W58957050 cites W2091951244 @default.
- W58957050 cites W2095152070 @default.
- W58957050 cites W2097122549 @default.
- W58957050 cites W2103673724 @default.
- W58957050 cites W2104549940 @default.
- W58957050 cites W2108563688 @default.
- W58957050 cites W2117535122 @default.
- W58957050 cites W2121771705 @default.
- W58957050 cites W2124200350 @default.
- W58957050 cites W2125879914 @default.
- W58957050 cites W2128530881 @default.
- W58957050 cites W2130483212 @default.
- W58957050 cites W2138257795 @default.
- W58957050 cites W2144183062 @default.
- W58957050 cites W2145068263 @default.
- W58957050 cites W2147988018 @default.
- W58957050 cites W2149522871 @default.
- W58957050 cites W2156319067 @default.
- W58957050 cites W2158721696 @default.
- W58957050 cites W2158817049 @default.
- W58957050 cites W2159289603 @default.
- W58957050 cites W2160773722 @default.
- W58957050 cites W2161427180 @default.
- W58957050 cites W2165508540 @default.
- W58957050 cites W2168132298 @default.
- W58957050 cites W2325008242 @default.
- W58957050 cites W2395795922 @default.
- W58957050 cites W79671651 @default.
- W58957050 cites W2340707994 @default.
- W58957050 cites W2511448464 @default.
- W58957050 hasPublicationYear "2010" @default.
- W58957050 type Work @default.
- W58957050 sameAs 58957050 @default.
- W58957050 citedByCount "0" @default.
- W58957050 crossrefType "dissertation" @default.
- W58957050 hasAuthorship W58957050A5016338164 @default.
- W58957050 hasConcept C126322002 @default.
- W58957050 hasConcept C137183658 @default.
- W58957050 hasConcept C15744967 @default.
- W58957050 hasConcept C163214680 @default.