Matches in SemOpenAlex for { <https://semopenalex.org/work/W58963145> ?p ?o ?g. }
- W58963145 abstract "The immune system plays a major role in the surveillance against tumors. To avoid attack from the immune system, tumor cells adapt different strategies to escape immune surveillance. Different approaches of immunotherapy have been developed based on the understanding of these strategies. Due to the random process of T cell receptor (TCR) rearrangement, autoreactive T cells responding to self-antigens are generated during the development of T cells in the thymus. To avoid autoimmune disease, the immune system must be tolerant to self-antigens. Immune tolerance can be divided into central tolerance and peripheral tolerance. Central tolerance is imposed during the development of T cells in the thymus, while peripheral tolerance occurs after T cells are exported into the periphery. Recent studies showed that inducing immune tolerance is one of the major strategies used by tumor cells to escape from immune surveillance. Since tumor cells express self-antigens that can be expressed in the thymus, tolerance to these tumor antigens can be induced in the thymus by clonal deletion. Another important mechanism of immune tolerance involves the function of regulatory T cells (Tregs). Tregs can be produced in either the thymus or in the periphery, but act in the periphery, particularly in the target tissue. The increased number of Tregs found in cancer patients and the existence of tumor specific-Tregs indicates that these cells may suppress the" @default.
- W58963145 created "2016-06-24" @default.
- W58963145 creator A5026513735 @default.
- W58963145 date "2009-01-01" @default.
- W58963145 modified "2023-09-27" @default.
- W58963145 title "Enhanced Anti-Tumor Immunity by Breaking Immune Tolerance." @default.
- W58963145 cites W146089551 @default.
- W58963145 cites W1482758361 @default.
- W58963145 cites W1483194800 @default.
- W58963145 cites W1486722793 @default.
- W58963145 cites W1489480103 @default.
- W58963145 cites W1493940088 @default.
- W58963145 cites W1514048512 @default.
- W58963145 cites W1517807114 @default.
- W58963145 cites W1521600055 @default.
- W58963145 cites W1530782041 @default.
- W58963145 cites W1541202713 @default.
- W58963145 cites W1546871754 @default.
- W58963145 cites W1552865668 @default.
- W58963145 cites W1555988808 @default.
- W58963145 cites W1560624221 @default.
- W58963145 cites W1565123196 @default.
- W58963145 cites W1573828236 @default.
- W58963145 cites W1575585006 @default.
- W58963145 cites W1580217007 @default.
- W58963145 cites W1589446607 @default.
- W58963145 cites W1606117344 @default.
- W58963145 cites W1622891121 @default.
- W58963145 cites W1642873092 @default.
- W58963145 cites W1643706151 @default.
- W58963145 cites W1664872521 @default.
- W58963145 cites W1665146230 @default.
- W58963145 cites W1676754695 @default.
- W58963145 cites W1708153904 @default.
- W58963145 cites W1793388556 @default.
- W58963145 cites W1863050266 @default.
- W58963145 cites W187972430 @default.
- W58963145 cites W1963832008 @default.
- W58963145 cites W1966020342 @default.
- W58963145 cites W1966178583 @default.
- W58963145 cites W1972187865 @default.
- W58963145 cites W1973690102 @default.
- W58963145 cites W1975993620 @default.
- W58963145 cites W1976774831 @default.
- W58963145 cites W1977273255 @default.
- W58963145 cites W1977775048 @default.
- W58963145 cites W1978988160 @default.
- W58963145 cites W1979618971 @default.
- W58963145 cites W1980299462 @default.
- W58963145 cites W1980486933 @default.
- W58963145 cites W1982021681 @default.
- W58963145 cites W1983350325 @default.
- W58963145 cites W1983427343 @default.
- W58963145 cites W1983519619 @default.
- W58963145 cites W1983664228 @default.
- W58963145 cites W1984915215 @default.
- W58963145 cites W1985406652 @default.
- W58963145 cites W1987203358 @default.
- W58963145 cites W1991526219 @default.
- W58963145 cites W1992832092 @default.
- W58963145 cites W1992847016 @default.
- W58963145 cites W1996029874 @default.
- W58963145 cites W2000900408 @default.
- W58963145 cites W2001169541 @default.
- W58963145 cites W2001621054 @default.
- W58963145 cites W2002038445 @default.
- W58963145 cites W2003257616 @default.
- W58963145 cites W2005542290 @default.
- W58963145 cites W2005721095 @default.
- W58963145 cites W2006987944 @default.
- W58963145 cites W2010057554 @default.
- W58963145 cites W2012241435 @default.
- W58963145 cites W2012515646 @default.
- W58963145 cites W2014066292 @default.
- W58963145 cites W2014900010 @default.
- W58963145 cites W2016671320 @default.
- W58963145 cites W2016983859 @default.
- W58963145 cites W2017728303 @default.
- W58963145 cites W2018091905 @default.
- W58963145 cites W2018227907 @default.
- W58963145 cites W2018703348 @default.
- W58963145 cites W2019214729 @default.
- W58963145 cites W2020111811 @default.
- W58963145 cites W2025909187 @default.
- W58963145 cites W2026891958 @default.
- W58963145 cites W2028222510 @default.
- W58963145 cites W2031274868 @default.
- W58963145 cites W2031722062 @default.
- W58963145 cites W2034269086 @default.
- W58963145 cites W2036097587 @default.
- W58963145 cites W2038354380 @default.
- W58963145 cites W2041049082 @default.
- W58963145 cites W2041354260 @default.
- W58963145 cites W2045246330 @default.
- W58963145 cites W2045932062 @default.
- W58963145 cites W2046185375 @default.
- W58963145 cites W2046972425 @default.
- W58963145 cites W2047203592 @default.
- W58963145 cites W2050252843 @default.
- W58963145 cites W2050253058 @default.