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- W58972020 abstract "A review of water-bulk solid pharmaceuticals interactions is carried out according to the different solids nature. In crystalline products water molecules can bound into their surface or penetrates into their structure, normally at low percentage, except of those hydrate forms of high orden. On the other hand, amorphous solids generally show higher amounts of water uptaken and clearly not stechiometrical, which is related with several important factors such as their hydrophylie or the environmental conditions. These presence of water can promote deep changes on drugs and excipients characteristics so it must be controlled. Finally the different techniques used in the cualitative and cuantitative water determination in solids-water systems are analyzed." @default.
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- W58972020 date "2004-01-01" @default.
- W58972020 modified "2023-10-17" @default.
- W58972020 title "Interacción sólido-agua. I. Estudio de las interacciones del agua con los sólidos farmacéuticos" @default.
- W58972020 hasPublicationYear "2004" @default.
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