SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W59067568> ?p ?o ?g. }

Showing items 1 to 100 of ±127 with 100 items per page.

W59067568 abstract "The kinetic resolution of a chiral ester by enzyme catalysed hydrolysis is a well-known process and is illustrated by the preparation of a synthon for the natural product coriolic acid. The stereoselective hydrolysis of meso-diesters can give rise to useful optically active intermediates e.g. for the synthesis of carbocyclic ribonucleosides. The enantioselective esterification of a bicyclic secondary alcohol has been used to give access to homochiral prostaglandin precursors. Acylases have been employed to hydrolyse a γ-lactam in enantiospecific fashion and the optically active materials obtained have been converted into the anti-HIV agent carbovir and into an unnatural amino-acid which binds to the GABA receptor. The natural β-amino-acid cispentacin has been prepared by a similar strategy. The less well-developed areas involving enzyme-catalysed hydrolysis of phosphate esters, epoxides and nitriles are also discussed. Reduction of substituted bicyclo[3.2.0]heptanones by dehydrogenase enzymes (either as isolated enzymes or within whole cell systems) gives rise to useful materials for the construction of the pheromone eldanolide and the chemokinetic agent leukotriene B4. Oxidation of benzene and derivatives by dioxygenase enzymes furnishes substituted cyclohexadienediols that can be modified by employing [4+2] and [2+2] cycloaddition reactions. The utility of the enzymic Baeyer Villiger reaction is exemplified by its use in the preparation of δ-lactones that can be converted into anti-HIV agents. Soybean lipoxygenase is useful for the synthesis of 13-HODE and analogues while the opportunities offered by organisms such as Beauveria sulfurescens, that are capable of oxidising organic substrates at ostensibly non-activated positions, are noted. Enzymes that catalyse formation of carbon-carbon bonds are of importance. The uses of rabbit muscle aldolase to form trioses and lyases to form cyanohydrins provide good examples. Amongst future developments in the field of biotransformations, the use of more than one enzyme in the same reaction vessel in order to catalyse a cascade of sequential reactions is a particularly attractive proposition." @default.
W59067568 created "2016-06-24" @default.
W59067568 creator A5071477576 @default.
W59067568 creator A5073735499 @default.
W59067568 date "1992-01-01" @default.
W59067568 modified "2023-10-05" @default.
W59067568 title "Use of Enzymes as Catalysts in Key Reactions Leading to the Synthesis of Optically Active Natural Products and Analogues" @default.
W59067568 cites W1965240883 @default.
W59067568 cites W1967840994 @default.
W59067568 cites W1969220241 @default.
W59067568 cites W1971961073 @default.
W59067568 cites W1973753734 @default.
W59067568 cites W1974389420 @default.
W59067568 cites W1980227065 @default.
W59067568 cites W1980990875 @default.
W59067568 cites W1981542683 @default.
W59067568 cites W1982304390 @default.
W59067568 cites W1990294207 @default.
W59067568 cites W1991543951 @default.
W59067568 cites W1995364476 @default.
W59067568 cites W1997528320 @default.
W59067568 cites W1999489191 @default.
W59067568 cites W2001361706 @default.
W59067568 cites W2002091786 @default.
W59067568 cites W2002643089 @default.
W59067568 cites W2003541451 @default.
W59067568 cites W2005833209 @default.
W59067568 cites W2006470564 @default.
W59067568 cites W2015192945 @default.
W59067568 cites W2015269563 @default.
W59067568 cites W2015454056 @default.
W59067568 cites W2015952818 @default.
W59067568 cites W2016527581 @default.
W59067568 cites W2025598832 @default.
W59067568 cites W2026829023 @default.
W59067568 cites W2034297848 @default.
W59067568 cites W2038279667 @default.
W59067568 cites W2038701253 @default.
W59067568 cites W2038875671 @default.
W59067568 cites W2039861079 @default.
W59067568 cites W2046701285 @default.
W59067568 cites W2049543544 @default.
W59067568 cites W2050137694 @default.
W59067568 cites W2050864728 @default.
W59067568 cites W2051273247 @default.
W59067568 cites W2051381003 @default.
W59067568 cites W2052885563 @default.
W59067568 cites W2053335601 @default.
W59067568 cites W2064444687 @default.
W59067568 cites W2065251867 @default.
W59067568 cites W2068301748 @default.
W59067568 cites W2069007939 @default.
W59067568 cites W2072415979 @default.
W59067568 cites W2076172897 @default.
W59067568 cites W2081005521 @default.
W59067568 cites W2083391723 @default.
W59067568 cites W2083556224 @default.
W59067568 cites W2085948050 @default.
W59067568 cites W2087891032 @default.
W59067568 cites W2088564485 @default.
W59067568 cites W2090253237 @default.
W59067568 cites W2094028951 @default.
W59067568 cites W2097719992 @default.
W59067568 cites W2103729373 @default.
W59067568 cites W2106419599 @default.
W59067568 cites W2122481050 @default.
W59067568 cites W2129503747 @default.
W59067568 cites W2143754984 @default.
W59067568 cites W2145130697 @default.
W59067568 cites W2151599723 @default.
W59067568 cites W2151616724 @default.
W59067568 cites W2156245902 @default.
W59067568 cites W2162957773 @default.
W59067568 cites W2163291106 @default.
W59067568 cites W2167408618 @default.
W59067568 cites W2171653221 @default.
W59067568 cites W2952339009 @default.
W59067568 cites W4244431368 @default.
W59067568 cites W82988049 @default.
W59067568 cites W96389920 @default.
W59067568 doi "https://doi.org/10.1007/978-94-011-2444-7_8" @default.
W59067568 hasPublicationYear "1992" @default.
W59067568 type Work @default.
W59067568 sameAs 59067568 @default.
W59067568 citedByCount "0" @default.
W59067568 crossrefType "book-chapter" @default.
W59067568 hasAuthorship W59067568A5071477576 @default.
W59067568 hasAuthorship W59067568A5073735499 @default.
W59067568 hasConcept C161790260 @default.
W59067568 hasConcept C166957645 @default.
W59067568 hasConcept C178790620 @default.
W59067568 hasConcept C185592680 @default.
W59067568 hasConcept C18903297 @default.
W59067568 hasConcept C21951064 @default.
W59067568 hasConcept C26517878 @default.
W59067568 hasConcept C2776608160 @default.
W59067568 hasConcept C3019471444 @default.
W59067568 hasConcept C86803240 @default.
W59067568 hasConcept C95457728 @default.
W59067568 hasConceptScore W59067568C161790260 @default.