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- W590764796 abstract "The inability of conventional GC/MS to adequately address the problems of analyzing molecules considered either thermally labile, of low volatility or of high polarity, has resulted in a number of different technological developments to help resolve difficult analytical situations. Over the last decade three main approaches have evolved to find practical application: the moving belt interface, direct liquid introduction and more recently in combination with supercritical fluid chromatography, and thermospray. For direct comparison of these different methods, a number of important criteria can facilitate the discussion of their relative strengths and weaknesses: eluant capacity, chromatographic resolution, sensitivity of detection, minimizing thermal degradation, choice of ionization method, limits of quantification, prolonged use, and cost factors. This tripartite array of LC/MS methods has resulted in the analytical capacity to successfully analyze those compounds normally not within the range of conventional GC/MS. The scientific literature has shown a dramatic increase in the number of LC/MS papers and reviews published that deal with analyzing polar molecules, both large and small." @default.
- W590764796 created "2016-06-24" @default.
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- W590764796 date "1990-02-22" @default.
- W590764796 modified "2023-10-04" @default.
- W590764796 title "Liquid Chromatography/Mass Spectrometry" @default.
- W590764796 doi "https://doi.org/10.1021/bk-1990-0420" @default.
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