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- W590983107 abstract "Objective To determine whether spinal cord stimulation (SCS) mitigates transient ischemia-induced ventricular infarction and, if so, whether timing of SCS onset impacts on such cardioprotection. Methods The hearts of anesthetized rabbits, subjected to 30 min of LAD coronary arterial occlusion (CAO) followed by 3 hr of reperfusion (control), were compared to those subjected to pre-emptive SCS (started 15 min prior to and continuing throughout the 30 min CAO) or reactive SCS (started at 1 min or 28′ of CAO and maintained throughout reperfusion). For SCS, the dorsal C8-T2 segments of the spinal cord were stimulated electrically (5 or 50 Hz; 0.2 ms; 90% of motor threshold). Infarct size (IS), measured by tetrazolium, was expressed as percentage of risk zone. Results In controls exposed to 30 min of CAO, IS was 36.4±9.5% (±SD). High frequency (50 Hz) pre-emptive SCS reduced IS to 21.8±6.8% (p<0.0001), a cardioprotective effect that was not present at 5 Hz SCS (IS = 36.1±9.1%). Reactive SCS did not reduce IS. C8-T2 SCS did not alter blood pressure or heart rate. Conclusions Pre-emptive SCS reduces the size of infarcts induced by transient CAO. Reactive SCS was ineffective in reducing infarct size, even when maintained into reperfusion. (HL71830)." @default.
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- W590983107 date "2006-03-01" @default.
- W590983107 modified "2023-09-22" @default.
- W590983107 title "Pre‐emptive, but not reactive, spinal cord stimulation mitigates transient ischemia induced myocardial infarction" @default.
- W590983107 doi "https://doi.org/10.1096/fasebj.20.5.a1206-b" @default.
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