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• W591084710 endingPage "120" @default.
• W591084710 startingPage "110" @default.
• W591084710 abstract "Brain plays a central role in energy homeostasis continuously integrating numerous peripheral signals such as circulating nutrients, and in particular blood glucose level, a variable that must be highly regulated. Then, the brain orchestrates adaptive responses to modulate food intake and peripheral organs activity in order to achieve the fine tuning of glycemia. More than fifty years ago, the presence of glucose-sensitive neurons was discovered in the hypothalamus, but what makes them specific and identifiable still remains disconnected from their electrophysiological signature. On the other hand, astrocytes represent the major class of macroglial cells and are now recognized to support an increasing number of neuronal functions. One of these functions consists in the regulation of energy homeostasis through neuronal fueling and nutrient sensing. Twenty years ago, we discovered that the glucose transporter GLUT2, the canonical glucosensor of the pancreatic beta-cell together with the glucokinase, was also present in astrocytes and participated in hypothalamic glucose sensing. Since then, many studies have identified other actors and emphasized the astroglial participation in this mechanism. Growing evidence suggest that astrocytes form a complex network and have to be considered as spatially coordinated and regulated metabolic units. In this review we aim to provide an updated view of the molecular and respective cellular pathways involved in hypothalamic glucose sensing, and their relevance in physiological and pathological states." @default.
• W591084710 created "2016-06-24" @default.
• W591084710 creator A5005538317 @default.
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• W591084710 creator A5014708404 @default.
• W591084710 creator A5046623286 @default.
• W591084710 creator A5082594265 @default.
• W591084710 date "2016-05-01" @default.
• W591084710 modified "2023-09-24" @default.
• W591084710 title "Glucose and hypothalamic astrocytes: More than a fueling role?" @default.
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