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- W59145245 abstract "Summary A clinical, immunologic and virologic work-up was undertaken in 425 symptom free multi-transfused patients with haemophilias or hemoglobinopathies. Patients were entered into 5 groups according to the type of blood product they received : domestic Factor VIII (group 1), a mixture of domestic and imported Factor VIII (group 2), imported Factor IX (group 3), domestic Factor IX (group 4) and washed red blood cells (group 5). A lymphopenia below 1 000 mm 3 was observed in 10 patients and was associated with other immunologic disturbances in 8. All groups of haemophiliacs had elevated T suppressor lymphocytes (TS) as compared to controls and patients in group 2 only had a significantly higher TS counts and lower TH/TS ratio than other haemophilic groups. IgG serum levels were significantly higher than control in all groups of patients and higher than haemophilic groups in group 2. Nine patients had cutaneous anergy always associated to other immunologic abnormalities. A correlation between treatment intensity and immune dysfunction was observed in patients treated with Factor VIII. The overall incidence of anti lymphadenopathy associated virus (LAV) IgG antibodies was 45%. The highest incidence was observed in group 2. Lymphadenopathies, abnormal skin tests and lymphopenia was detected at a significantly higher rate in LAV antibody positive subjects. This study has shown the prominent role of LAV in the occurrence of immunologic disturbances in multitransfused patients. However, allogenic proteins, present in Factor VIII but not in Factor IX preparations, seem to play a role of immuno-compromising agent. The interplay between LAV and additional factors possibly leading to AIDS remains to be analyzed." @default.
- W59145245 created "2016-06-24" @default.
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- W59145245 date "1985-05-01" @default.
- W59145245 modified "2023-09-27" @default.
- W59145245 title "L'état immunitaire des hémophiles" @default.
- W59145245 doi "https://doi.org/10.1016/s0399-077x(85)80293-6" @default.
- W59145245 hasPublicationYear "1985" @default.
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