Matches in SemOpenAlex for { <https://semopenalex.org/work/W591733807> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W591733807 endingPage "220" @default.
- W591733807 startingPage "202" @default.
- W591733807 abstract "In order to investigate the pathogenesis of cleft palate induced by a neuroleptic drug of phenothiazine derivatives, SD-rat fetuses were treated with perphenazine hydrochloride (PPZ) and examined by light and electron microscopy. The levels of corticosterone in maternal serum also were measured. The fetuses from dams treated orally with 50mg/kg on days from 13 to 15 of gestation showed inhibition of growth and a high frequency (87.5%) of cleft palates with micrognathia. Fetal mortality, however, was not significantly increased in treated groups. The corticosterone levels in maternal serum were 836.3μg/dl after 3 hours of treatment and 856.0μg/dl after 8 hours of treatment. In contrast, dams treated with combined PPZ and metyrapone (25mg/kg, subcutaneously injected twice a day) had reduced corticosterone levels (248μg/dl after 3 hours and 411.8μg/dl after 8 hours of treatment). At day 16, the palatal shelves in control fetuse started to elevate horizontally. Two horizontal palatal shelves then contacted each other and began to fuse. Long microvilli and small spherical body were observed at the epithelial surfaces of medial edges of both palatal shelves before fusion. The palatal shelves of fetuses in PPZ-treated groups were still vertically oriented even on days 17-20. Like the control groups, long microvilli and small spherical body also were observed at the epithelial surfaces of the medial edges of both palatal shelves. In fetuses having cleft palates from dams treated with the combined use of PPZ and metyrapone, the degree of morphological abnormalities was milder than that induced by PPZ alone. These results suggest that the development of cleft palates induced by PPZ in rat fetuses is caused primarily by the increased corticosterone levels in maternal serum." @default.
- W591733807 created "2016-06-24" @default.
- W591733807 creator A5086273699 @default.
- W591733807 date "1995-01-01" @default.
- W591733807 modified "2023-09-26" @default.
- W591733807 title "Histological Study on the Development of Cleft Palate in Perphenazine-treated Rat Fetus, with Special Reference to the Relationship between Corticosterone and Morphogenesis of the Secondary Palate" @default.
- W591733807 cites W1830098218 @default.
- W591733807 cites W1967008509 @default.
- W591733807 cites W1969795691 @default.
- W591733807 cites W1982209470 @default.
- W591733807 cites W1982318689 @default.
- W591733807 cites W2008524890 @default.
- W591733807 cites W2011819759 @default.
- W591733807 cites W2013751946 @default.
- W591733807 cites W2017292534 @default.
- W591733807 cites W2029689784 @default.
- W591733807 cites W2036466244 @default.
- W591733807 cites W2040723686 @default.
- W591733807 cites W2043874826 @default.
- W591733807 cites W2057306466 @default.
- W591733807 cites W2083143460 @default.
- W591733807 cites W2091354650 @default.
- W591733807 cites W2091583732 @default.
- W591733807 cites W2092217326 @default.
- W591733807 cites W2095230743 @default.
- W591733807 cites W2129794832 @default.
- W591733807 cites W2143100677 @default.
- W591733807 cites W2257878291 @default.
- W591733807 cites W2322540943 @default.
- W591733807 doi "https://doi.org/10.2504/kds.49.202" @default.
- W591733807 hasPublicationYear "1995" @default.
- W591733807 type Work @default.
- W591733807 sameAs 591733807 @default.
- W591733807 citedByCount "0" @default.
- W591733807 crossrefType "journal-article" @default.
- W591733807 hasAuthorship W591733807A5086273699 @default.
- W591733807 hasBestOaLocation W5917338071 @default.
- W591733807 hasConcept C105702510 @default.
- W591733807 hasConcept C126322002 @default.
- W591733807 hasConcept C134018914 @default.
- W591733807 hasConcept C172680121 @default.
- W591733807 hasConcept C2776719974 @default.
- W591733807 hasConcept C2776743534 @default.
- W591733807 hasConcept C2779234561 @default.
- W591733807 hasConcept C2780216207 @default.
- W591733807 hasConcept C2780352252 @default.
- W591733807 hasConcept C46973012 @default.
- W591733807 hasConcept C54355233 @default.
- W591733807 hasConcept C71315377 @default.
- W591733807 hasConcept C71924100 @default.
- W591733807 hasConcept C86803240 @default.
- W591733807 hasConceptScore W591733807C105702510 @default.
- W591733807 hasConceptScore W591733807C126322002 @default.
- W591733807 hasConceptScore W591733807C134018914 @default.
- W591733807 hasConceptScore W591733807C172680121 @default.
- W591733807 hasConceptScore W591733807C2776719974 @default.
- W591733807 hasConceptScore W591733807C2776743534 @default.
- W591733807 hasConceptScore W591733807C2779234561 @default.
- W591733807 hasConceptScore W591733807C2780216207 @default.
- W591733807 hasConceptScore W591733807C2780352252 @default.
- W591733807 hasConceptScore W591733807C46973012 @default.
- W591733807 hasConceptScore W591733807C54355233 @default.
- W591733807 hasConceptScore W591733807C71315377 @default.
- W591733807 hasConceptScore W591733807C71924100 @default.
- W591733807 hasConceptScore W591733807C86803240 @default.
- W591733807 hasIssue "2" @default.
- W591733807 hasLocation W5917338071 @default.
- W591733807 hasOpenAccess W591733807 @default.
- W591733807 hasPrimaryLocation W5917338071 @default.
- W591733807 hasRelatedWork W1974359230 @default.
- W591733807 hasRelatedWork W1976021903 @default.
- W591733807 hasRelatedWork W1986144760 @default.
- W591733807 hasRelatedWork W1993795923 @default.
- W591733807 hasRelatedWork W2027061752 @default.
- W591733807 hasRelatedWork W2053467161 @default.
- W591733807 hasRelatedWork W2078830738 @default.
- W591733807 hasRelatedWork W2095329316 @default.
- W591733807 hasRelatedWork W2397705441 @default.
- W591733807 hasRelatedWork W2156499933 @default.
- W591733807 hasVolume "49" @default.
- W591733807 isParatext "false" @default.
- W591733807 isRetracted "false" @default.
- W591733807 magId "591733807" @default.
- W591733807 workType "article" @default.