Matches in SemOpenAlex for { <https://semopenalex.org/work/W592038723> ?p ?o ?g. }
- W592038723 endingPage "354" @default.
- W592038723 startingPage "343" @default.
- W592038723 abstract "Malignant lymphomas represent a remarkably heterogeneous group of cancers with respect to their oncogenome, phenotype and clinical presentation. Lymphoma cells benefit from limited immune surveillance and have developed various mechanisms to alter antitumor immune responses. This article summarizes our current knowledge about genomic alterations underlying acquired immune privilege in lymphoid cancers.The implementation and broad application of next-generation sequencing techniques have significantly expanded our knowledge about genetic alterations and perturbed cellular pathways underlying lymphomagenesis. Based on key discoveries in the past decade, the purview of subsequent studies expanded beyond the biology of the lymphoma cells to include the pathogenic contribution of immune cells, stromal components and associated crosstalk between malignant and nonmalignant cells in the tumor microenvironment. A number of genetic mechanisms have been described that elucidate how lymphoma cells are selected for evading immune recognition and reprogramming immune responses. These prominently include structural genomic changes of the CIITA and programmed death ligand (CD274/PDCD1LG2) loci, alterations affecting antigen presentation and mutations in JAK-STAT and NFκB signaling pathways.Further investigations will foster our understanding about synergy of immune escape mechanisms, and lay the foundation for the development of predictive biomarkers in the context of conceptually novel therapies targeting microenvironment-related biology, such as immunological checkpoint inhibition." @default.
- W592038723 created "2016-06-24" @default.
- W592038723 creator A5048030695 @default.
- W592038723 creator A5086655742 @default.
- W592038723 date "2015-07-01" @default.
- W592038723 modified "2023-09-25" @default.
- W592038723 title "Genomic alterations underlying immune privilege in malignant lymphomas" @default.
- W592038723 cites W1479772224 @default.
- W592038723 cites W1533021978 @default.
- W592038723 cites W1538902372 @default.
- W592038723 cites W1553927017 @default.
- W592038723 cites W1575965151 @default.
- W592038723 cites W1586649168 @default.
- W592038723 cites W1853154894 @default.
- W592038723 cites W1900801624 @default.
- W592038723 cites W1925763316 @default.
- W592038723 cites W1952554789 @default.
- W592038723 cites W1956285448 @default.
- W592038723 cites W1964481268 @default.
- W592038723 cites W1970006069 @default.
- W592038723 cites W1971408711 @default.
- W592038723 cites W1971659434 @default.
- W592038723 cites W1971873029 @default.
- W592038723 cites W1975272871 @default.
- W592038723 cites W1976524637 @default.
- W592038723 cites W1976564639 @default.
- W592038723 cites W1976590012 @default.
- W592038723 cites W1981431992 @default.
- W592038723 cites W1981858590 @default.
- W592038723 cites W1983632629 @default.
- W592038723 cites W1984484036 @default.
- W592038723 cites W1985106225 @default.
- W592038723 cites W1986354050 @default.
- W592038723 cites W1987608235 @default.
- W592038723 cites W1988924112 @default.
- W592038723 cites W1992081197 @default.
- W592038723 cites W1994993231 @default.
- W592038723 cites W1995338244 @default.
- W592038723 cites W1996080482 @default.
- W592038723 cites W1997325736 @default.
- W592038723 cites W1999578399 @default.
- W592038723 cites W2001663034 @default.
- W592038723 cites W2003262666 @default.
- W592038723 cites W2003874772 @default.
- W592038723 cites W2004495270 @default.
- W592038723 cites W2008890632 @default.
- W592038723 cites W2010052935 @default.
- W592038723 cites W2011228017 @default.
- W592038723 cites W2015410907 @default.
- W592038723 cites W2016487786 @default.
- W592038723 cites W2017712207 @default.
- W592038723 cites W2018161209 @default.
- W592038723 cites W2024040061 @default.
- W592038723 cites W2024790681 @default.
- W592038723 cites W2026336857 @default.
- W592038723 cites W2026496528 @default.
- W592038723 cites W2028376975 @default.
- W592038723 cites W2031855605 @default.
- W592038723 cites W2033632793 @default.
- W592038723 cites W2035135710 @default.
- W592038723 cites W2035235332 @default.
- W592038723 cites W2035518124 @default.
- W592038723 cites W2036958461 @default.
- W592038723 cites W2037796411 @default.
- W592038723 cites W2038070878 @default.
- W592038723 cites W2041598067 @default.
- W592038723 cites W2044227662 @default.
- W592038723 cites W2048790475 @default.
- W592038723 cites W2050387997 @default.
- W592038723 cites W2051083170 @default.
- W592038723 cites W2051344486 @default.
- W592038723 cites W2051940153 @default.
- W592038723 cites W2053146807 @default.
- W592038723 cites W2053334297 @default.
- W592038723 cites W2054076276 @default.
- W592038723 cites W2054519090 @default.
- W592038723 cites W2057499380 @default.
- W592038723 cites W2061123122 @default.
- W592038723 cites W2061548387 @default.
- W592038723 cites W2064610182 @default.
- W592038723 cites W2066763506 @default.
- W592038723 cites W2067158363 @default.
- W592038723 cites W2070873336 @default.
- W592038723 cites W2072448714 @default.
- W592038723 cites W2076948707 @default.
- W592038723 cites W2082073431 @default.
- W592038723 cites W2082519303 @default.
- W592038723 cites W2085252246 @default.
- W592038723 cites W2088513299 @default.
- W592038723 cites W2090149541 @default.
- W592038723 cites W2090505632 @default.
- W592038723 cites W2090627430 @default.
- W592038723 cites W2096964576 @default.
- W592038723 cites W2097056602 @default.
- W592038723 cites W2097583243 @default.
- W592038723 cites W2098186012 @default.
- W592038723 cites W2098677328 @default.
- W592038723 cites W2100024378 @default.