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- W59280666 abstract "Tephrosia purpurea leaves were studied for its protective and curative effect against gentamicin-induced acute renal injury in albino rats of both sexes. The maximum free radical scavenging activity of ethanolic extract was made the basis of selection of this extract for in vivo study. In study, gentamicin intoxication caused significant increase in blood urea (69.48 ± 4.34) and serum creatinine (3.017 ± 0.208) from normal levels 33.72± 1.92 and 0.818 ± 0.073, respectively, in control group. In the preventive regimen, the extract (200 mg/kg) showed significant reduction in the elevated blood urea (45.44 ± 1.88) and serum creatinine (1.84 ± 0.192), respectively. Histopathological changes were in line with biochemical findings. In the curative regimen (200 mg/kg) blood urea was found to be 41.21 ± 2.28 and serum creatinine level was 1.42 ± 0.122, which revealed significant curative effect. In vivo antioxidant activity was also determined. Reduced glutathione (GSH) level was significantly (P< 0.05) increased in the extract treated groups whereas malondialdehyde (MDA) was reduced significantly (P< 0.05). The findings suggest that the ethanol extract of Tephrosia purpurea leaves possesses marked nephroprotective and curative activities without any toxicity. The proposed mechanisms of activities are antioxidant activity and inhibition of overproduction of NO and Cox-2 expression. It is further concluded the activities may be attributed to phenolic and flavonoidal compounds like quercetin. Our study reveled that Tephrosia purpurea could offer a promising role in the treatment of acute renal injury caused by nephrotoxin like gentamicin." @default.
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- W59280666 date "2009-01-01" @default.
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- W59280666 title "Effect of Tephrosia Purpurea Pers on Gentamicin Model of Acute Renal Failure" @default.
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- W59280666 doi "https://doi.org/10.1007/978-3-540-92841-6_355" @default.
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