Matches in SemOpenAlex for { <https://semopenalex.org/work/W593158384> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W593158384 abstract "Most theories concerning the primary cause of Crohn's disease focus on over-activation of the immune response. Paradoxically, the defect may instead relate to diminished acute inflammation. Neutrophil accumulation to sites of dermal trauma has been shown to be reduced. Were the same phenomenon to occur in the gut, it might impair bacterial clearance thus provoking granuloma formation. In this thesis, a novel technique demonstrated attenuated neutrophil accumulation following trauma to the bowel. A modified skin window technique linked this failure of migration to defective IL-8 production. Polymorphisms in CARD15, associated with susceptibility to Crohn's disease, compounded the problem by abrogating the normal pro-inflammatory action of the protein but did not underlie the basic phenotype. Consequently, the response of macrophages to other inflammatory agonists was examined. IL-8 production was also impaired in Crohn's disease after stimulation with wound fluid, C5a or TNF-a. The response of Crohn's patients to gut bacteria was assessed directly in vivo by subcutaneous injection of killed Escherichia coli. This elicited substantial local inflammation in controls, manifested by an NO-mediated increase in blood flow. The response was considerably lower in Crohn's patients, particular those with colonic disease. In contrast, acute phase reactants were highest in the latter, supporting the hypothesis that an impaired local response can drive a systemic pro inflammatory state. The demonstration of attenuated acute inflammation in Crohn's disease may have important implications for understanding its pathogenesis and targeting novel therapies." @default.
- W593158384 created "2016-06-24" @default.
- W593158384 creator A5056135297 @default.
- W593158384 date "2006-01-01" @default.
- W593158384 modified "2023-09-28" @default.
- W593158384 title "Investigation of the acute inflammatory response in Crohn's disease." @default.
- W593158384 hasPublicationYear "2006" @default.
- W593158384 type Work @default.
- W593158384 sameAs 593158384 @default.
- W593158384 citedByCount "0" @default.
- W593158384 crossrefType "dissertation" @default.
- W593158384 hasAuthorship W593158384A5056135297 @default.
- W593158384 hasConcept C142724271 @default.
- W593158384 hasConcept C203014093 @default.
- W593158384 hasConcept C2776914184 @default.
- W593158384 hasConcept C2778260677 @default.
- W593158384 hasConcept C2779134260 @default.
- W593158384 hasConcept C2779280984 @default.
- W593158384 hasConcept C2780942790 @default.
- W593158384 hasConcept C71924100 @default.
- W593158384 hasConcept C8891405 @default.
- W593158384 hasConceptScore W593158384C142724271 @default.
- W593158384 hasConceptScore W593158384C203014093 @default.
- W593158384 hasConceptScore W593158384C2776914184 @default.
- W593158384 hasConceptScore W593158384C2778260677 @default.
- W593158384 hasConceptScore W593158384C2779134260 @default.
- W593158384 hasConceptScore W593158384C2779280984 @default.
- W593158384 hasConceptScore W593158384C2780942790 @default.
- W593158384 hasConceptScore W593158384C71924100 @default.
- W593158384 hasConceptScore W593158384C8891405 @default.
- W593158384 hasLocation W5931583841 @default.
- W593158384 hasOpenAccess W593158384 @default.
- W593158384 hasPrimaryLocation W5931583841 @default.
- W593158384 hasRelatedWork W1982082531 @default.
- W593158384 hasRelatedWork W2021205628 @default.
- W593158384 hasRelatedWork W2030174698 @default.
- W593158384 hasRelatedWork W2040552223 @default.
- W593158384 hasRelatedWork W2041084237 @default.
- W593158384 hasRelatedWork W2061266734 @default.
- W593158384 hasRelatedWork W2073146140 @default.
- W593158384 hasRelatedWork W2073715731 @default.
- W593158384 hasRelatedWork W2074349892 @default.
- W593158384 hasRelatedWork W2094100492 @default.
- W593158384 hasRelatedWork W2129853439 @default.
- W593158384 hasRelatedWork W2136700988 @default.
- W593158384 hasRelatedWork W2139090780 @default.
- W593158384 hasRelatedWork W2148670192 @default.
- W593158384 hasRelatedWork W2158293388 @default.
- W593158384 hasRelatedWork W2313076964 @default.
- W593158384 hasRelatedWork W2329822565 @default.
- W593158384 hasRelatedWork W2354156338 @default.
- W593158384 hasRelatedWork W2526371708 @default.
- W593158384 hasRelatedWork W66466603 @default.
- W593158384 isParatext "false" @default.
- W593158384 isRetracted "false" @default.
- W593158384 magId "593158384" @default.
- W593158384 workType "dissertation" @default.