Matches in SemOpenAlex for { <https://semopenalex.org/work/W59324957> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W59324957 endingPage "194" @default.
- W59324957 startingPage "183" @default.
- W59324957 abstract "Analysis of independently isolated clones from a mouse liver cDNA library identified a splice variant of gamma-GH mRNA with novel nucleotide sequence at the 5' end. Genomic sequencing now shows that this variant (variant II) incorporates two new alternates (exons Bla and Blb) of exon 1 in the murine gamma-GH gene remotely situated with respect to the rest of the gene. Further analysis of this variant also showed that it incorporates a small segment at the 3' end of exon A1, revealing that the previously described exon 1 consists of two individual exons (Ala and Alb) joined at a cryptic splice site. The 5' UTR and a segment of the ORF of variant II results from splicing of exon Bla to exon Blb which in turn is spliced to exon Alb and through this splicing to the rest of the exons within this gene. Remarkably, this splicing occurs even though exons Bla and Blb are located >45 Kb upstream of exons Ala and Alb. Our results also show that transcription starting at exons Bla and Blb is under the control of a separate and bidirectional promoter (promoter B). Exons Bla and Blb are located on the sense DNA strand within the complement C3 gene locus which is encoded on the antisense strand. This promoter is less efficient than the downstream promoter (promoter A) in regulating transcription at least in the context of reporter gene and primer extension assays. However, in these same contexts, this region of DNA sequence in the reverse orientation is markedly more efficient in driving transcription of an unidentified gene. Deletion of specific regions of sequence within this promoter have different effects depending upon the orientation (forward or reverse) within the reporter gene construct." @default.
- W59324957 created "2016-06-24" @default.
- W59324957 creator A5031676422 @default.
- W59324957 creator A5066518191 @default.
- W59324957 creator A5069747635 @default.
- W59324957 date "2001-05-01" @default.
- W59324957 modified "2023-09-27" @default.
- W59324957 title "Additional organizational features of the murine γ-glutamyl hydrolase gene" @default.
- W59324957 cites W1547081765 @default.
- W59324957 cites W1577623248 @default.
- W59324957 cites W1980469685 @default.
- W59324957 cites W1986071829 @default.
- W59324957 cites W1990043928 @default.
- W59324957 cites W2006004944 @default.
- W59324957 cites W2009397884 @default.
- W59324957 cites W2014485481 @default.
- W59324957 cites W2019111444 @default.
- W59324957 cites W2025633862 @default.
- W59324957 cites W2027672309 @default.
- W59324957 cites W2031267689 @default.
- W59324957 cites W2038419615 @default.
- W59324957 cites W2053006426 @default.
- W59324957 cites W2054342062 @default.
- W59324957 cites W2093191788 @default.
- W59324957 cites W2095531021 @default.
- W59324957 cites W2149195756 @default.
- W59324957 cites W2151625863 @default.
- W59324957 cites W4210954947 @default.
- W59324957 cites W2143925292 @default.
- W59324957 doi "https://doi.org/10.1016/s0378-1119(01)00411-5" @default.
- W59324957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11368914" @default.
- W59324957 hasPublicationYear "2001" @default.
- W59324957 type Work @default.
- W59324957 sameAs 59324957 @default.
- W59324957 citedByCount "5" @default.
- W59324957 countsByYear W593249572013 @default.
- W59324957 crossrefType "journal-article" @default.
- W59324957 hasAuthorship W59324957A5031676422 @default.
- W59324957 hasAuthorship W59324957A5066518191 @default.
- W59324957 hasAuthorship W59324957A5069747635 @default.
- W59324957 hasConcept C101762097 @default.
- W59324957 hasConcept C104317684 @default.
- W59324957 hasConcept C150194340 @default.
- W59324957 hasConcept C153911025 @default.
- W59324957 hasConcept C156446351 @default.
- W59324957 hasConcept C17757408 @default.
- W59324957 hasConcept C190017056 @default.
- W59324957 hasConcept C194583182 @default.
- W59324957 hasConcept C36823959 @default.
- W59324957 hasConcept C39917842 @default.
- W59324957 hasConcept C54355233 @default.
- W59324957 hasConcept C54458228 @default.
- W59324957 hasConcept C62257209 @default.
- W59324957 hasConcept C67705224 @default.
- W59324957 hasConcept C86803240 @default.
- W59324957 hasConcept C94671646 @default.
- W59324957 hasConceptScore W59324957C101762097 @default.
- W59324957 hasConceptScore W59324957C104317684 @default.
- W59324957 hasConceptScore W59324957C150194340 @default.
- W59324957 hasConceptScore W59324957C153911025 @default.
- W59324957 hasConceptScore W59324957C156446351 @default.
- W59324957 hasConceptScore W59324957C17757408 @default.
- W59324957 hasConceptScore W59324957C190017056 @default.
- W59324957 hasConceptScore W59324957C194583182 @default.
- W59324957 hasConceptScore W59324957C36823959 @default.
- W59324957 hasConceptScore W59324957C39917842 @default.
- W59324957 hasConceptScore W59324957C54355233 @default.
- W59324957 hasConceptScore W59324957C54458228 @default.
- W59324957 hasConceptScore W59324957C62257209 @default.
- W59324957 hasConceptScore W59324957C67705224 @default.
- W59324957 hasConceptScore W59324957C86803240 @default.
- W59324957 hasConceptScore W59324957C94671646 @default.
- W59324957 hasIssue "1-2" @default.
- W59324957 hasLocation W593249571 @default.
- W59324957 hasLocation W593249572 @default.
- W59324957 hasOpenAccess W59324957 @default.
- W59324957 hasPrimaryLocation W593249571 @default.
- W59324957 hasRelatedWork W1532050162 @default.
- W59324957 hasRelatedWork W1790903453 @default.
- W59324957 hasRelatedWork W1926883706 @default.
- W59324957 hasRelatedWork W2094710038 @default.
- W59324957 hasRelatedWork W2121781238 @default.
- W59324957 hasRelatedWork W2126974438 @default.
- W59324957 hasRelatedWork W2136735424 @default.
- W59324957 hasRelatedWork W2167440544 @default.
- W59324957 hasRelatedWork W4239231391 @default.
- W59324957 hasRelatedWork W4252868546 @default.
- W59324957 hasVolume "268" @default.
- W59324957 isParatext "false" @default.
- W59324957 isRetracted "false" @default.
- W59324957 magId "59324957" @default.
- W59324957 workType "article" @default.