Matches in SemOpenAlex for { <https://semopenalex.org/work/W59365174> ?p ?o ?g. }
- W59365174 endingPage "162" @default.
- W59365174 startingPage "149" @default.
- W59365174 abstract "After antigen binding, a subset of newly activated B and T cells is recruited into the primary follicles of lymphoid tissue where, along with follicular dendritic cells, they establish a site of vigorous lymphocyte proliferation. Within these germinal centers the processes of somatic hypermutation and selection result in the affinity maturation of antigen receptors (see, e.g., Kelsoe 1996; Wagner and Neuberger 1996). Mutation rates at the rearranged V(D)J locus and the flanking introns are up to 106 times higher than background. During the germinal center reaction, the affinities of immunoglobulins (Igs) for the eliciting antigen typically increase by factors of ten or 100 in the B cells that go on to become memory cells. Using antigen as a limited resource in a miniaturized Darwinian struggle for survival among lymphocytes is an essential component of the overall strategy employed by the immune system to effectively combat the vast majority of pathogens. Somatic mutation — though not necessarily accompanied by affinity maturation — has been described in many species, including, remarkably, (Hinds-Frey et al. 1993), the earliest extant animal with an adaptive immune system (Du Pasquier 1993)" @default.
- W59365174 created "2016-06-24" @default.
- W59365174 creator A5009660879 @default.
- W59365174 creator A5047959968 @default.
- W59365174 date "1998-01-01" @default.
- W59365174 modified "2023-09-26" @default.
- W59365174 title "Plasticity Under Somatic Mutation in Antigen Receptors" @default.
- W59365174 cites W1548757996 @default.
- W59365174 cites W1549511338 @default.
- W59365174 cites W1565321014 @default.
- W59365174 cites W1579000294 @default.
- W59365174 cites W169978917 @default.
- W59365174 cites W1713239852 @default.
- W59365174 cites W1730140814 @default.
- W59365174 cites W1964933368 @default.
- W59365174 cites W1978817164 @default.
- W59365174 cites W1986136768 @default.
- W59365174 cites W1986884580 @default.
- W59365174 cites W1986945726 @default.
- W59365174 cites W1987263883 @default.
- W59365174 cites W2005566446 @default.
- W59365174 cites W2017533703 @default.
- W59365174 cites W2028296100 @default.
- W59365174 cites W2028555129 @default.
- W59365174 cites W2031011895 @default.
- W59365174 cites W2035757181 @default.
- W59365174 cites W2056384440 @default.
- W59365174 cites W2064390120 @default.
- W59365174 cites W2064438534 @default.
- W59365174 cites W2066347271 @default.
- W59365174 cites W2091974060 @default.
- W59365174 cites W2096832116 @default.
- W59365174 cites W2125409137 @default.
- W59365174 cites W2140385774 @default.
- W59365174 cites W2145533125 @default.
- W59365174 cites W2154735764 @default.
- W59365174 cites W2163282567 @default.
- W59365174 cites W2176905394 @default.
- W59365174 cites W2396823695 @default.
- W59365174 doi "https://doi.org/10.1007/978-3-642-71984-4_11" @default.
- W59365174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9479853" @default.
- W59365174 hasPublicationYear "1998" @default.
- W59365174 type Work @default.
- W59365174 sameAs 59365174 @default.
- W59365174 citedByCount "7" @default.
- W59365174 crossrefType "book-chapter" @default.
- W59365174 hasAuthorship W59365174A5009660879 @default.
- W59365174 hasAuthorship W59365174A5047959968 @default.
- W59365174 hasConcept C104317684 @default.
- W59365174 hasConcept C128526571 @default.
- W59365174 hasConcept C134305767 @default.
- W59365174 hasConcept C13514818 @default.
- W59365174 hasConcept C147483822 @default.
- W59365174 hasConcept C153911025 @default.
- W59365174 hasConcept C159654299 @default.
- W59365174 hasConcept C193419808 @default.
- W59365174 hasConcept C203014093 @default.
- W59365174 hasConcept C2776090121 @default.
- W59365174 hasConcept C2778453870 @default.
- W59365174 hasConcept C2781377902 @default.
- W59365174 hasConcept C3753494 @default.
- W59365174 hasConcept C501734568 @default.
- W59365174 hasConcept C54355233 @default.
- W59365174 hasConcept C67662055 @default.
- W59365174 hasConcept C86803240 @default.
- W59365174 hasConcept C8891405 @default.
- W59365174 hasConcept C95444343 @default.
- W59365174 hasConcept C96926380 @default.
- W59365174 hasConceptScore W59365174C104317684 @default.
- W59365174 hasConceptScore W59365174C128526571 @default.
- W59365174 hasConceptScore W59365174C134305767 @default.
- W59365174 hasConceptScore W59365174C13514818 @default.
- W59365174 hasConceptScore W59365174C147483822 @default.
- W59365174 hasConceptScore W59365174C153911025 @default.
- W59365174 hasConceptScore W59365174C159654299 @default.
- W59365174 hasConceptScore W59365174C193419808 @default.
- W59365174 hasConceptScore W59365174C203014093 @default.
- W59365174 hasConceptScore W59365174C2776090121 @default.
- W59365174 hasConceptScore W59365174C2778453870 @default.
- W59365174 hasConceptScore W59365174C2781377902 @default.
- W59365174 hasConceptScore W59365174C3753494 @default.
- W59365174 hasConceptScore W59365174C501734568 @default.
- W59365174 hasConceptScore W59365174C54355233 @default.
- W59365174 hasConceptScore W59365174C67662055 @default.
- W59365174 hasConceptScore W59365174C86803240 @default.
- W59365174 hasConceptScore W59365174C8891405 @default.
- W59365174 hasConceptScore W59365174C95444343 @default.
- W59365174 hasConceptScore W59365174C96926380 @default.
- W59365174 hasLocation W593651741 @default.
- W59365174 hasLocation W593651742 @default.
- W59365174 hasOpenAccess W59365174 @default.
- W59365174 hasPrimaryLocation W593651741 @default.
- W59365174 hasRelatedWork W1963720100 @default.
- W59365174 hasRelatedWork W1971344703 @default.
- W59365174 hasRelatedWork W1998079194 @default.
- W59365174 hasRelatedWork W2005463221 @default.
- W59365174 hasRelatedWork W2069891517 @default.
- W59365174 hasRelatedWork W2120114799 @default.