FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W59367931> ?p ?o ?g. }

• W59367931 abstract "Hypoxia in cystic fibrosis (CF) may occur during sleep, and also during exercise, chest exacerbations and air travel. No standardised definition of nocturnal hypoxia in CF exists. Theoretical evidence suggests hypoxia may have a deleterious impact on clinical status in CF, due to effects on upregulation of pro-inflammatory cytokines, changes in Pseudomonas aeruginosa growth patterns, and causation of pulmonary hypertension. It was hypothesised that hypoxia, and resultant inflammation would adversely affect clinical phenotype in CF. Forty-one children with CF were studied, each undergoing home oximetry before attending for a day of clinical testing (exercise testing, lung function, respiratory and skeletal muscle testing, echocardiography, and quality of life assessment). In vitro work was undertaken to assess the effects of hypoxia on cell growth and interleukin-8 (IL-8) secretion in wild-type and CF airway epithelial cells. The effects of hypoxia were compared to a known proinflammatory stimulus - lipopolysaccharide (LPS) from Pseudomonas aeruginosa. ROC statistics were used to derive the most sensitive and specific definition of sleep hypoxia in the detection of elevated levels of inflammation (WBC, CRP, neutrophil counts and IL-8 levels). This definition (SpO2 10% sleep) was used to dichotomise the study population. Hypoxic CF subjects (n=9) had, when compared to normoxic controls (n=32): lower exercise capacity, lower BMI, lower FEV1 and FVC, elevated RV/TLC ratio, and higher Chrispin-Norman scores. Hypoxic subjects also had reduced quality of life, bone density, and increased RV thickness on echocardiogram. Hypoxic cell culture was suggested to be pro-inflammatory, with increased IL-8 production, and synergistically increased IL-8 secretion when cells were co-incubated with LPS under hypoxic conditions. Hypoxia is associated with reduced clinical well-being and increased inflammation in childhood CF. The paradigm exists of whether hypoxia is merely an endpoint of severe CF lung disease; or whether hypoxia may be a causative factor (as suggested by the in vitro work), as well as an effect of CF lung inflammation. A trial of restoration of normoxia in children with CF, with careful re-evaluation of clinically-relevant outcomes is suggested from this preliminary work." @default.
• W59367931 created "2016-06-24" @default.
• W59367931 creator A5032796903 @default.
• W59367931 date "2010-01-01" @default.
• W59367931 modified "2023-09-26" @default.
• W59367931 title "Exploration of the relationship between hypoxia and measures of clinical status and inflammation in children with cystic fibrosis" @default.
• W59367931 cites W118353332 @default.
• W59367931 cites W1464400763 @default.
• W59367931 cites W1487235492 @default.
• W59367931 cites W1515994079 @default.
• W59367931 cites W1532516694 @default.
• W59367931 cites W1546399014 @default.
• W59367931 cites W1558367558 @default.
• W59367931 cites W1672218564 @default.
• W59367931 cites W1708240703 @default.
• W59367931 cites W1832661589 @default.
• W59367931 cites W1869391303 @default.
• W59367931 cites W1891743888 @default.
• W59367931 cites W1902994327 @default.
• W59367931 cites W1903677522 @default.
• W59367931 cites W1947063211 @default.
• W59367931 cites W1952023912 @default.
• W59367931 cites W1964133839 @default.
• W59367931 cites W1966528088 @default.
• W59367931 cites W1967279039 @default.
• W59367931 cites W1969391391 @default.
• W59367931 cites W1971926198 @default.
• W59367931 cites W1972213770 @default.
• W59367931 cites W1977129537 @default.
• W59367931 cites W1981434879 @default.
• W59367931 cites W1982749799 @default.
• W59367931 cites W1982760987 @default.
• W59367931 cites W1984837505 @default.
• W59367931 cites W1985106459 @default.
• W59367931 cites W1985619693 @default.
• W59367931 cites W1985690299 @default.
• W59367931 cites W1985931793 @default.
• W59367931 cites W1988696782 @default.
• W59367931 cites W1988810577 @default.
• W59367931 cites W1989694167 @default.
• W59367931 cites W1991940128 @default.
• W59367931 cites W1992141724 @default.
• W59367931 cites W1992628574 @default.
• W59367931 cites W1994285771 @default.
• W59367931 cites W1997712031 @default.
• W59367931 cites W1997811592 @default.
• W59367931 cites W1998195903 @default.
• W59367931 cites W2005269914 @default.
• W59367931 cites W2011496352 @default.
• W59367931 cites W2013340198 @default.
• W59367931 cites W2015655339 @default.
• W59367931 cites W2015795623 @default.
• W59367931 cites W2016276671 @default.
• W59367931 cites W2016772500 @default.
• W59367931 cites W2019604979 @default.
• W59367931 cites W2021285446 @default.
• W59367931 cites W2022634662 @default.
• W59367931 cites W2027703997 @default.
• W59367931 cites W2029955786 @default.
• W59367931 cites W2030686502 @default.
• W59367931 cites W2032146334 @default.
• W59367931 cites W2032258216 @default.
• W59367931 cites W2038033588 @default.
• W59367931 cites W2039195061 @default.
• W59367931 cites W2040470926 @default.
• W59367931 cites W2042293234 @default.
• W59367931 cites W2044346818 @default.
• W59367931 cites W2044826456 @default.
• W59367931 cites W2044942738 @default.
• W59367931 cites W2046621499 @default.
• W59367931 cites W2047381800 @default.
• W59367931 cites W2047868790 @default.
• W59367931 cites W2048237871 @default.
• W59367931 cites W2051839369 @default.
• W59367931 cites W2052497181 @default.
• W59367931 cites W2052590343 @default.
• W59367931 cites W2055601663 @default.
• W59367931 cites W2056840878 @default.
• W59367931 cites W2057061730 @default.
• W59367931 cites W2057119680 @default.
• W59367931 cites W2057618822 @default.
• W59367931 cites W2061816753 @default.
• W59367931 cites W2068359901 @default.
• W59367931 cites W2068532436 @default.
• W59367931 cites W2071367248 @default.
• W59367931 cites W2072830629 @default.
• W59367931 cites W2073727172 @default.
• W59367931 cites W2075082585 @default.
• W59367931 cites W2075481642 @default.
• W59367931 cites W2077570040 @default.
• W59367931 cites W2079750805 @default.
• W59367931 cites W2083300606 @default.
• W59367931 cites W2083565359 @default.
• W59367931 cites W2084029271 @default.
• W59367931 cites W2084126269 @default.
• W59367931 cites W2085236767 @default.
• W59367931 cites W2086577836 @default.
• W59367931 cites W2087225497 @default.
• W59367931 cites W2089303149 @default.
• W59367931 cites W2089896788 @default.

• next