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- W59383458 abstract "The in vivo effect of a basic phospholipase from the venom of Naja nigricollis was investigated. Purified phospholipase was administered intravenously into mice, and the lungs, kidneys and blood cells were examined by electronmicroscopy. Distinct pathological changes appeared in mice receiving 400 μ/kg or more. The erythrocytes underwent transformation to spherocytes, fragmentation and hemolysis. The endothelial cells in the pulmonary capillaries showed focal swelling with development of small processes from the cell membranes and pinching off of small membrane fragments. There was a general congestion of the blood vessels. In the kidneys the endothelial cells of the peritubular vessels underwent changes similar to those observed in the lung. Characteristic lesions appeared in the proximal and distal tubular cells with dissolution of the vasal labyrinthic membrane structure. Animals receiving porcine phospholipase showed slight ruptures in the endothelium of the peritubular vessels, but no other pathological changes were observed. The significance of these findings is discussed." @default.
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- W59383458 date "1980-01-01" @default.
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- W59383458 title "ULTRASTRUCTURAL CHANGES IN THE LUNGS, KIDNEYS AND ERYTHROCYTES AFTER NAJA NIGRICOLLIS BASIC PHOSPHOLIPASE ADMINISTRATION" @default.
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- W59383458 doi "https://doi.org/10.1016/b978-0-08-024952-0.50010-7" @default.
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