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- W59395725 abstract "This chapter discusses the molecular physiology of mammalian epithelial Na+/H+ exchangers (NHE)—NHE2 and NHE3. These two exchangers contribute to small intestinal, colonic, gallbladder, renal, and salivary gland Na+ and HCO3– absorption and, along with ENaC and Na+-linked substrate cotransporters, carry out most of the renal and intestinal Na+ absorption. The chapter provides an overview of NHEs, including the identified members of the Na+/H+ exchanger gene family and the structure/function relationships of the NHE N terminus; cellular and subcellular locations; physiological functions of apical Membrane NHEs and those attributed to NHE2 and/or NHE3; the regulation of transport activity; and diseases in which the epithelial NHEs play a pathogenic role. NHE2 and NHE3 can alter intracellular pH and intracellular volume. The cloned NHE isoforms are all separate genes and, with one exception, are present on different chromosomes. The related NHE2 and NHE4 are on the same chromosome. Pseudogenes are identified only for NHE3. All members of the NHE gene family have similar membrane topology based on similarity in hydrophobicity predicted by multiple algorithms. The chapter also describes the method used to assess the topology of NHE3 and NHE2." @default.
- W59395725 created "2016-06-24" @default.
- W59395725 creator A5044859707 @default.
- W59395725 creator A5052599296 @default.
- W59395725 date "2000-01-01" @default.
- W59395725 modified "2023-10-16" @default.
- W59395725 title "Chapter 12 Molecular physiology of mammalian epithelial Na+/H+ exchangers NHE2 and NHE3" @default.
- W59395725 cites W1481519187 @default.
- W59395725 cites W1482741711 @default.
- W59395725 cites W1483932465 @default.
- W59395725 cites W1486242268 @default.
- W59395725 cites W1494739644 @default.
- W59395725 cites W1518461235 @default.
- W59395725 cites W1530129745 @default.
- W59395725 cites W1530463005 @default.
- W59395725 cites W1543811682 @default.
- W59395725 cites W1545097323 @default.
- W59395725 cites W1546275634 @default.
- W59395725 cites W1553426129 @default.
- W59395725 cites W1554264637 @default.
- W59395725 cites W1554578780 @default.
- W59395725 cites W1562578444 @default.
- W59395725 cites W1565223184 @default.
- W59395725 cites W1572775048 @default.
- W59395725 cites W1573745866 @default.
- W59395725 cites W1575941030 @default.
- W59395725 cites W1578170165 @default.
- W59395725 cites W1580672895 @default.
- W59395725 cites W1589657989 @default.
- W59395725 cites W1593418419 @default.
- W59395725 cites W1602747859 @default.
- W59395725 cites W1603470245 @default.
- W59395725 cites W1607594871 @default.
- W59395725 cites W1768624324 @default.
- W59395725 cites W1858501591 @default.
- W59395725 cites W189305868 @default.
- W59395725 cites W1900337562 @default.
- W59395725 cites W1900598585 @default.
- W59395725 cites W1950300271 @default.
- W59395725 cites W1964136985 @default.
- W59395725 cites W1965144258 @default.
- W59395725 cites W1971052608 @default.
- W59395725 cites W1971584001 @default.
- W59395725 cites W1972654175 @default.
- W59395725 cites W1973480659 @default.
- W59395725 cites W1973582318 @default.
- W59395725 cites W1973989870 @default.
- W59395725 cites W1974615597 @default.
- W59395725 cites W1975748795 @default.
- W59395725 cites W1976620024 @default.
- W59395725 cites W1977739714 @default.
- W59395725 cites W1980728293 @default.
- W59395725 cites W1981295957 @default.
- W59395725 cites W1981707775 @default.
- W59395725 cites W1982620154 @default.
- W59395725 cites W1983884349 @default.
- W59395725 cites W1988083468 @default.
- W59395725 cites W1989519336 @default.
- W59395725 cites W1991664547 @default.
- W59395725 cites W1991843145 @default.
- W59395725 cites W1994379611 @default.
- W59395725 cites W1996355148 @default.
- W59395725 cites W1997301069 @default.
- W59395725 cites W1998626317 @default.
- W59395725 cites W1998704876 @default.
- W59395725 cites W1999529375 @default.
- W59395725 cites W2000298437 @default.
- W59395725 cites W2001415405 @default.
- W59395725 cites W2004104084 @default.
- W59395725 cites W2004347894 @default.
- W59395725 cites W2006234322 @default.
- W59395725 cites W2007836537 @default.
- W59395725 cites W2008899035 @default.
- W59395725 cites W2009847006 @default.
- W59395725 cites W2011478292 @default.
- W59395725 cites W2012151229 @default.
- W59395725 cites W2016516976 @default.
- W59395725 cites W2019200153 @default.
- W59395725 cites W2019490673 @default.
- W59395725 cites W2019786947 @default.
- W59395725 cites W2021687262 @default.
- W59395725 cites W2022394342 @default.
- W59395725 cites W2022678476 @default.
- W59395725 cites W2023329018 @default.
- W59395725 cites W2024028178 @default.
- W59395725 cites W2024358879 @default.
- W59395725 cites W2025100148 @default.
- W59395725 cites W2027470864 @default.
- W59395725 cites W2030192076 @default.
- W59395725 cites W2033066722 @default.
- W59395725 cites W2033990219 @default.
- W59395725 cites W2035276578 @default.
- W59395725 cites W2036822252 @default.
- W59395725 cites W2038836890 @default.
- W59395725 cites W2039975259 @default.
- W59395725 cites W2040951085 @default.
- W59395725 cites W2042294891 @default.
- W59395725 cites W2042416952 @default.