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- W59409346 abstract "Synthetic and naturally occurring antioxidants have a wide variety of biological actions in rodents, in addition to their primary antioxidant activity. Many of these antioxidants are examined in the chapter for their ability to induce proliferative activity in the alimentary canal. These investigations reveal that the caffeic acid and sesamol are tumorigenic for rat fore-stomach epithelium, whereas catechol and p-methylcatechol induce neoplasia in rat glandular stomach epithelium. Chronic irritation is considered to be responsible for the induction of stomach cancer by antioxidants. The human risk assessment of phenolic antioxidant exposure, and the extrapolation from experimental data, takes into account the target organ, dose level, and route of administration. Some of the necessary characteristics for an ideal chemopreventer include lack of genotoxicity, lack of carcinogenicity, ability to inhibit initiation activity, ability to inhibit promotion activity, and ability to block nitrosamine formation. The fact that antioxidants may show opposite effects in different organs particularly in the promotion stage, implies that a total-body approach using different carcinogenic initiators is necessary for the reliable assessment of second-stage effects." @default.
- W59409346 created "2016-06-24" @default.
- W59409346 creator A5041911355 @default.
- W59409346 creator A5054388953 @default.
- W59409346 date "1989-01-01" @default.
- W59409346 modified "2023-09-30" @default.
- W59409346 title "Antioxidants-Carcinogenic and Chemopreventive Properties" @default.
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