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- W59419110 abstract "Tryptamine (T) is a neuroactive compound which is found in trace amounts throughout the mouse CNS with the highest levels occurring in the caudate nucleus (Juorio and Durden, 1984). In addition, subcellular fractionation studies have revealed that T is primarily localized in the synaptosomal fraction and, thus, may be neuronal in origin (Boulton and Baker, 1975). Furthermore, Juorio and Greenshaw (1986) have recently demonstrated by unilateral electrolytic lesions of the rat substantia nigra that T appears to exist in neurons of the nigrostriatal pathway. Autoradiographic studies of the distribution of T binding sites in rat brain have similarly demonstrated that the striatum also contains moderately high concentrations of T receptors (Altar et al., 1986). Thus, evidence for the presence of both pre- and post-synaptic components of a tryptaminergic system indicate that T may play a neurotransmitter role in the striatum." @default.
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- W59419110 date "1988-01-01" @default.
- W59419110 modified "2023-09-24" @default.
- W59419110 title "Tryptamine Turnover: Effects of Drugs" @default.
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