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• W594832503 abstract "OBJECTIVE: To explore the prevalence of cerebral amyloid angiopathy (CAA) in persons with autosomal dominant Alzheimer disease (ADAD).BACKGROUND: As anti-amyloid therapies for AD can cause intracerebral edema and hemorrhage, possibly related to CAA, it is becoming more relevant to identify CAA. Prevention studies employing anti-amyloid therapies are underway in persons inheriting fully-penetrant ADAD mutations (in the PSEN1, APP, and PSEN2 genes), populations in which the prevalence of CAA is incompletely characterized.DESIGN/METHODS: We queried the National Alzheimer Coordinating Center (NACC) database for autopsy data on subjects known to have had ADAD mutations and subjects with Uniform Data Set (UDS) data who died with clinical diagnoses of AD and were not suspected of having a genetic abnormality. An additional 7 non-NACC ADAD cases from UCLA were also included. We compared the prevalence of no, mild, moderate, or severe CAA between ADAD cases and “sporadic” AD and between PSEN1 cases with mutations before or after codon 200 using chi-square tests.RESULTS: Fifty-six persons with ADAD mutations (PSEN1 = 42, APP = 10, PSEN2 = 4, mean age of 53 years) were compared to 150 persons with sporadic AD (mean age 79 years). Persons dying with ADAD were more likely to have moderate or severe CAA (62.5[percnt]) than persons with sporadic AD (45.3[percnt], p = 0.027). Among persons with PSEN1 mutations, the prevalence of moderate or severe CAA in persons having a mutation beyond codon 200 (85[percnt], n = 20) was greater than in persons have a mutation before codon 200 (43.5[percnt], n = 23, p = 0.013).CONCLUSIONS: Moderate to severe CAA is a more common finding at autopsy in ADAD than sporadic AD, suggesting that increased vigilance for CAA-related complications of anti-amyloid therapy is warranted in this population.Study Supported by: NIH P50 AG016570, U01 AG016976, U19 AG032438, UL1TR000124 Disclosure: Dr. Ringman has received research support from Janssen, Pfizer, Accera, Bristol Myers Squibb, and Wyeth Pharmaceuticals. Dr. Monsell has nothing to disclose. Dr. Nguyen has nothing to disclose. Dr. Tung has nothing to disclose. Dr. Zhou has nothing to disclose. Dr. Ng has nothing to disclose. Dr. Vinters has nothing to disclose." @default.
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• W594832503 date "2015-04-06" @default.
• W594832503 modified "2023-09-23" @default.
• W594832503 title "Prevalence of cerebral amyloid angiopathy on autopsy in autosomal dominant Alzheimer’s disease (S33.008)" @default.
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