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- W595123010 abstract "Twenty five 4, 6-dichlorobenzimidazole derivatives (1-25) have been synthesized and evaluated against β-glucuronidase inhibitory activity. The compounds which actively inhibit β-glucuronidase activity have IC50 values ranging between 4.48 and 46.12 μM and showing better than standard d-saccharic acid 1,4 lactone (IC50=48.4 ± 1.25 μM). Molecular docking provided potential clues to identify interactions between the active molecules and the enzyme which further led us to identify plausible binding mode of all the benzimidazole derivatives. This study confirmed that presence of hydrophilic moieties is crucial to inhibit the human β-glucuronidase." @default.
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- W595123010 date "2015-08-01" @default.
- W595123010 modified "2023-09-23" @default.
- W595123010 title "Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors" @default.
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- W595123010 doi "https://doi.org/10.1016/j.bioorg.2015.05.010" @default.
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