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- W59547358 abstract "It has been shown that the magnitude of long-term potentiation (LTP) is reduced in the noradrenaline (NA) depleted rats. This chapter discusses the possible significance of this finding for models of the physiological basis of learning. The high frequency trains of stimuli delivered to the fibers of the perforant path lead to increases in the efficacy of its synaptic connections with the granule cells of the dentate gyrus. The increase has been shown to persist for several hours in the anesthetized animal and for longer in the awake animal with chronically indwelling electrodes. This LTP of synaptic efficacy provides a model for the study of physiological mechanisms, which may underlie learning and memory. Evidence from a number of sources shows that anatomical and functional types of synaptic plasticity may be dependent on the integrity of the noradrenergic projection." @default.
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- W59547358 date "1981-01-01" @default.
- W59547358 modified "2023-10-16" @default.
- W59547358 title "NORADRENALINE DEPLETION REDUCES LONG TERM POTENTIATION IN THE RAT HIPPOCAMPUS" @default.
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- W59547358 doi "https://doi.org/10.1016/b978-0-08-027372-3.50021-6" @default.
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