Matches in SemOpenAlex for { <https://semopenalex.org/work/W595838858> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W595838858 abstract "The solubility and dissolution behaviour of hydrophobic and hydrophilic sparingly soluble drugs is discussed in this thesis. The roles of varying particle dimensions, disordered (amorphous) solid structures and the coexistence of amorphous and crystalline phases, especially on the surfaces of particles with a crystalline core, are evaluated in this context.A simplified solubility model, based on the application of a wide range of dispersion concentrations during the characterisation of saturation concentrations (apparent solubilities), is proposed in order to qualitatively describe the relationship between established apparent solubilities and different combinations of solid structures.Several solubility plateaux were found, for a range of practically insoluble materials, in a plot of the established saturation concentration versus dispersion concentration. The lowest and highest solubility plateaux correspond to the solubilities of the totally ordered and totally disordered standards (one-component model). An intermediate plateau serves as an indication of the existence of a totally semiordered structure (one-component model) Such a structure was proposed for one type of quenched griseofulvin, where the prepared particles were described as glassy and homogeneously semiordered.However, the saturation concentrations of two-component materials, containing a partly or totally disordered solid surface on a crystalline core (obtained by milling or mixing) were significantly dependent on the dispersion concentration, only reaching the plateau saturation concentrations of the totally disordered or semiordered one-component standards at very high dispersion concentrations. The dissolution rate profiles of solids with a peripheral disordered layer, in contrast to those of totally crystalline solids, were biphasic, which indicates that the solid state structure and solid state reactivity of the inter-phase will affect the dissolution rate of a drug. It was also shown that the effects of particle dimensions on the intrinsic dissolution rate of a drug are not limited to the interfacial surface area. It is suggested that the thickness of the diffusion layer controlling the dissolution rate is a function of both the size and shape of the particle (i.e. it decreases for small, isodiametric particles), thus linking dissolution and particle hydrodynamics.Alterations to a recently developed method for determining the solubility of practically insoluble drugs, using the Coulter counter technique, are also presented. This method now allows detection of the solubility of drugs at concentrations as low as 0.1 ppm." @default.
- W595838858 created "2016-06-24" @default.
- W595838858 creator A5052590635 @default.
- W595838858 date "1999-12-01" @default.
- W595838858 modified "2023-09-23" @default.
- W595838858 title "The Effects of Solid State Properties on Solubility and in Vitro Dissolution Behaviour of Suspended Sparingly Soluble Drugs" @default.
- W595838858 hasPublicationYear "1999" @default.
- W595838858 type Work @default.
- W595838858 sameAs 595838858 @default.
- W595838858 citedByCount "3" @default.
- W595838858 crossrefType "book" @default.
- W595838858 hasAuthorship W595838858A5052590635 @default.
- W595838858 hasConcept C114614502 @default.
- W595838858 hasConcept C120665830 @default.
- W595838858 hasConcept C121332964 @default.
- W595838858 hasConcept C127413603 @default.
- W595838858 hasConcept C155574463 @default.
- W595838858 hasConcept C177562468 @default.
- W595838858 hasConcept C178790620 @default.
- W595838858 hasConcept C185592680 @default.
- W595838858 hasConcept C192562407 @default.
- W595838858 hasConcept C199289684 @default.
- W595838858 hasConcept C33923547 @default.
- W595838858 hasConcept C42360764 @default.
- W595838858 hasConcept C56052488 @default.
- W595838858 hasConcept C8010536 @default.
- W595838858 hasConcept C88380143 @default.
- W595838858 hasConcept C9930424 @default.
- W595838858 hasConceptScore W595838858C114614502 @default.
- W595838858 hasConceptScore W595838858C120665830 @default.
- W595838858 hasConceptScore W595838858C121332964 @default.
- W595838858 hasConceptScore W595838858C127413603 @default.
- W595838858 hasConceptScore W595838858C155574463 @default.
- W595838858 hasConceptScore W595838858C177562468 @default.
- W595838858 hasConceptScore W595838858C178790620 @default.
- W595838858 hasConceptScore W595838858C185592680 @default.
- W595838858 hasConceptScore W595838858C192562407 @default.
- W595838858 hasConceptScore W595838858C199289684 @default.
- W595838858 hasConceptScore W595838858C33923547 @default.
- W595838858 hasConceptScore W595838858C42360764 @default.
- W595838858 hasConceptScore W595838858C56052488 @default.
- W595838858 hasConceptScore W595838858C8010536 @default.
- W595838858 hasConceptScore W595838858C88380143 @default.
- W595838858 hasConceptScore W595838858C9930424 @default.
- W595838858 hasLocation W5958388581 @default.
- W595838858 hasOpenAccess W595838858 @default.
- W595838858 hasPrimaryLocation W5958388581 @default.
- W595838858 hasRelatedWork W1415789720 @default.
- W595838858 hasRelatedWork W178423137 @default.
- W595838858 hasRelatedWork W1971393964 @default.
- W595838858 hasRelatedWork W1978473617 @default.
- W595838858 hasRelatedWork W1983099595 @default.
- W595838858 hasRelatedWork W1989380925 @default.
- W595838858 hasRelatedWork W1996253167 @default.
- W595838858 hasRelatedWork W2017186239 @default.
- W595838858 hasRelatedWork W2038666676 @default.
- W595838858 hasRelatedWork W2055825990 @default.
- W595838858 hasRelatedWork W2059918315 @default.
- W595838858 hasRelatedWork W2077563626 @default.
- W595838858 hasRelatedWork W2078216749 @default.
- W595838858 hasRelatedWork W2081617630 @default.
- W595838858 hasRelatedWork W2135561299 @default.
- W595838858 hasRelatedWork W2141304800 @default.
- W595838858 hasRelatedWork W2323749857 @default.
- W595838858 hasRelatedWork W2564045133 @default.
- W595838858 hasRelatedWork W2980094916 @default.
- W595838858 hasRelatedWork W2069099788 @default.
- W595838858 isParatext "false" @default.
- W595838858 isRetracted "false" @default.
- W595838858 magId "595838858" @default.
- W595838858 workType "book" @default.