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- W595924991 abstract "Stimulation of purinergic receptors and the evoked rise in endothelial cell calcium, initiate the release of various factors that can lead to vasodilation. Increasing the intraluminal rate of flow can also initiate endothelium-dependent vasorelaxation. In rat small mesenteric arteries, neither flow nor ATP alone can stimulate robust dilatation, yet when flow is introduced in the presence of luminal ATP, marked blood vessel relaxation can be obtained (Liu et al. Am. J. Physiol Heart Circ. Physiol. 2004; 286: –1695). Both P2X and P2Y receptors can mediate the action of ATP and these receptors are expressed on both endothelial and smooth muscle cells. Therefore to assess the direct contribution by the endothelium, endothelial cells were freshly isolated from rat small mesenteric arteries, and changes in intracellular levels in response to flow and purinerigic agonists measured using confocal microscopy. Consistent with the results obtained for vasodilatation in intact vessels, no flow-dependent changes in intracellular endothelial cell Ca2+ could be observed. ATP, ADPβ-S, Bz-ATP each stimulated robust and sustained increases in cytoplasmic Ca2+, but this was not dependent on flow. These data indicate that isolation of endothelial cells appears to bypass the requirement for the interaction between flow and purinergic receptor stimulation. This may be due to the importance of cell-cell interactions in the wall of the artery and/or a specific cytoskeletal arrangement. Supported by the Wellcome Trust, UK" @default.
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- W595924991 date "2006-03-01" @default.
- W595924991 modified "2023-09-26" @default.
- W595924991 title "Lack of synergism between flow and ATP in stimulating increases in vascular endothelial cell [Ca2+]i" @default.
- W595924991 doi "https://doi.org/10.1096/fasebj.20.4.a669-b" @default.
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