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- W59616462 abstract "Abstract Decellularization protocols for both whole organs and tissue parts have been developed and successful for many organs but not for the thymus. The decellularization process maintains the integrity of the organ by preserving the components of the extracellular matrix, including proteins such as collagen and fibronectin. This allows for an acellular, three dimensional biological scaffold of the desired organ which can then be repopulated with cells. Routine decellularization techniques published for other tissue such as the heart and the lung were inadequate for the thymus and ablated the extracellular matrix. Novel techniques were discovered. The aim of this project is to apply the idea of decellularization to the thymus, using thymic tissue procured from murine, porcine, and human models. Thymic tissue has been decellularized using two methods; SDS (sodium dodecyl sulfate) based protocols and by Deoxycholic Acid/Triton-X mixture protocols, and examined for remnant cells and extracellular proteins through histological staining and SEM imaging. We have confirmed complete decelluarization with murine thymic tissue and are advancing to porcine and human samples. We have identified varying decelluarization techniques that provide multiple degrees of integrity of the extra cellular matrix. These techniques may be used in tissue engineering strategies to repopulate a thymic construct for thymic reconstitution." @default.
- W59616462 created "2016-06-24" @default.
- W59616462 creator A5022225112 @default.
- W59616462 date "2013-05-01" @default.
- W59616462 modified "2023-10-16" @default.
- W59616462 title "Techniques for thymic decellularization (P3392)" @default.
- W59616462 doi "https://doi.org/10.4049/jimmunol.190.supp.135.28" @default.
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