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- W596379931 abstract "Focal adhesion kinase (FAK) and paxillin are proteins implicated in the mechanisms that link chronic alterations in mechanical force within skeletal muscle and its microvasculature to the functional adaptation seen with changes in physical activity. This thesis developed novel immunofluorescence microscopy methods to visualise and measure FAK and paxillin responses in human skeletal muscle and its microvasculature. Chapter 2 reveals high FAK protein content in the (sub)sarcolemma of skeletal muscle fibres and within the microvascular endothelial and vascular smooth muscle cell layers. Chapter 3 demonstrates that FAK protein content is increased at (sub)sarcolemmal and sarcoplasmic regions of skeletal muscle fibres and within the microvascular endothelium following 12 weeks resistance-type exercise training in elderly individuals. Chapter 4 shows that FAK and paxillin colocalise at the (sub)sarcolemma of skeletal muscle fibres and within the microvasculature. Chapter 5 demonstrates that FAK and paxillin are increased at the (sub)sarcolemma and within the microvascular endothelium following 6 weeks endurance- and resistance-type exercise training in young previously sedentary individuals. The novel data generated in this thesis, in combination with recent literature findings, support the hypothesis that FAK and paxillin play an important role in upstream mechanotransduction signals that control skeletal muscle fibre hypertrophy, mitochondrial biogenesis, insulin sensitivity, microvascular function and angiogenesis." @default.
- W596379931 created "2016-06-24" @default.
- W596379931 creator A5067710676 @default.
- W596379931 date "2014-07-01" @default.
- W596379931 modified "2023-09-24" @default.
- W596379931 title "Visualisation of focal adhesion-associated proteins in the skeletal muscle of young and elderly individuals: effect of exercise training" @default.
- W596379931 cites W1565396177 @default.
- W596379931 cites W1572889665 @default.
- W596379931 cites W1573938781 @default.
- W596379931 cites W1597933301 @default.
- W596379931 cites W1608211496 @default.
- W596379931 cites W1672030686 @default.
- W596379931 cites W1794129251 @default.
- W596379931 cites W1838896829 @default.
- W596379931 cites W1870980090 @default.
- W596379931 cites W1915029257 @default.
- W596379931 cites W1941414980 @default.
- W596379931 cites W1958496312 @default.
- W596379931 cites W1965336601 @default.
- W596379931 cites W1968989744 @default.
- W596379931 cites W1971474283 @default.
- W596379931 cites W1973032213 @default.
- W596379931 cites W1973793244 @default.
- W596379931 cites W1979073379 @default.
- W596379931 cites W1979365820 @default.
- W596379931 cites W1990864597 @default.
- W596379931 cites W1992546098 @default.
- W596379931 cites W1992610736 @default.
- W596379931 cites W1993994764 @default.
- W596379931 cites W1997591046 @default.
- W596379931 cites W1998813619 @default.
- W596379931 cites W2002973721 @default.
- W596379931 cites W2003037315 @default.
- W596379931 cites W2005804402 @default.
- W596379931 cites W2009910680 @default.
- W596379931 cites W2010102296 @default.
- W596379931 cites W2016779327 @default.
- W596379931 cites W2017353764 @default.
- W596379931 cites W2018247073 @default.
- W596379931 cites W2020267609 @default.
- W596379931 cites W2023087041 @default.
- W596379931 cites W2024029655 @default.
- W596379931 cites W2027390836 @default.
- W596379931 cites W202848394 @default.
- W596379931 cites W2028691987 @default.
- W596379931 cites W2031569153 @default.
- W596379931 cites W2032104153 @default.
- W596379931 cites W2038273086 @default.
- W596379931 cites W2039773817 @default.
- W596379931 cites W2040072240 @default.
- W596379931 cites W2041065162 @default.
- W596379931 cites W2044422396 @default.
- W596379931 cites W2056498562 @default.
- W596379931 cites W2058425999 @default.
- W596379931 cites W2065363098 @default.
- W596379931 cites W2069674130 @default.
- W596379931 cites W2072399660 @default.
- W596379931 cites W2073967350 @default.
- W596379931 cites W2077163123 @default.
- W596379931 cites W2078726855 @default.
- W596379931 cites W2082466944 @default.
- W596379931 cites W2087036507 @default.
- W596379931 cites W2089950181 @default.
- W596379931 cites W2091448352 @default.
- W596379931 cites W2093190999 @default.
- W596379931 cites W2097670341 @default.
- W596379931 cites W2099023724 @default.
- W596379931 cites W2101802733 @default.
- W596379931 cites W2101877733 @default.
- W596379931 cites W2102837285 @default.
- W596379931 cites W2102862733 @default.
- W596379931 cites W2104683776 @default.
- W596379931 cites W2106384285 @default.
- W596379931 cites W2106560234 @default.
- W596379931 cites W2106643427 @default.
- W596379931 cites W2110114155 @default.
- W596379931 cites W2110843541 @default.
- W596379931 cites W2113427441 @default.
- W596379931 cites W2113612408 @default.
- W596379931 cites W2115150337 @default.
- W596379931 cites W2118035665 @default.
- W596379931 cites W2118874116 @default.
- W596379931 cites W2119150168 @default.
- W596379931 cites W2119544098 @default.
- W596379931 cites W2122953585 @default.
- W596379931 cites W2123064842 @default.
- W596379931 cites W2123809226 @default.
- W596379931 cites W2125644189 @default.
- W596379931 cites W2128195376 @default.
- W596379931 cites W2132665092 @default.
- W596379931 cites W2132806001 @default.
- W596379931 cites W2133374963 @default.
- W596379931 cites W2133915158 @default.
- W596379931 cites W2134613826 @default.
- W596379931 cites W2135375808 @default.
- W596379931 cites W2136051455 @default.
- W596379931 cites W2138867813 @default.
- W596379931 cites W2138885158 @default.
- W596379931 cites W2139055395 @default.
- W596379931 cites W2141075109 @default.