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• W596455593 abstract "In the present study, the experiments were designed to characterize some pharmacological actions of Cardiocrome on cardiovascular systems and leukopenias of some animals. Cardiocrome is the activator of tissue respiration, which is the admixture consisted of cytochrome c, cocarboxylase and riboflavin phosphate. Effects of Cardiocrome on systemic blood pressure, heart rate, contraction of isolated atria, coronary circulation, ventricular fibrillation and leukopenia were compared with the effects of cytochrome c in dogs, cats, rabbits and guinea-pigs. In dogs, intravenous or intracarotid injection of Cardiocrome resulted in a depressions of the systemic blood pressure and of the heart rate and an increase of the blood flows in the carotid artery and the brain tissue. In cats also, intravenous injection of Cardiocrome showed the same results on the effects on the systemic blood pressure and the heart rate. When such the effects of Cardiocrome was compared with that of cytochrome c, the latter was excessively weak than the former. In the isolated guinea-pig atria, an administration of Cardiocrome induced a temporary depression of the contractile force, but the force was shortly recovered to the previous level. On the other hand, an administration of cytochrome c induced an irreversible depression of the contractile force. In the dog coronary circulation model, intracoronary injection of Cardiocrome induced a depression of the systemic and the coronary perfusional blood pressure, an increase of the coronary blood flow and a secondary increase followed by a primary depression of the cardiac muscular contractile force, unlike cytochrome c. Such the effects of cytochrome c were weaker than Cardiocrome. Above the results suggest that Cardiocrome has characteristic actions of a remarkable vascular dilation and a primary depression and a secondary increase in the cardiac muscular contractile force, unlike cytochrome c. It may be presumed that these actions of Cardiocrome is owing to both the reagents, cocarboxylase and riboflavin phosphate, contained in Cardiocrome. In rabbits, intravenous injection of Cardiocrome or cytochrome c delayed the death caused by ventricular fibrillation induced by KCl and showed a survival effect. However, this phenomenon was not observed in the case without the injection of the both reagents. In addition, the reduction of number of the leucocyte of rabbits by Nitromin was not depressed with the intravenous injection of Cardiocrome or cytochrome c, but when the administration of Nitromin was discontinued, they were more effective in the increase and recovery in the number of leucocyte reduced by Nitromin, as compared with physiological saline." @default.
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• W596455593 date "1983-01-01" @default.
• W596455593 modified "2023-10-05" @default.
• W596455593 title "Effects of Cardiocrome on Cardiovascular Systems and Leukopenia of Animals" @default.
• W596455593 doi "https://doi.org/10.2504/kds.37.114" @default.
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