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- W59646629 abstract "Soy protein (SP) and soy isoflavones may slow bone loss. While many studies have examined the effects of feeding SP and/or isoflavones on ovariectomized rats, a model of postmenopausal bone loss, little has been done with animal models of Ca deficiency. Ca deficiency decreases bone growth and causes bone loss, and serves as a model of osteoporosis. In this study we examined the effects of feeding SP or SP plus isoflavones on bone metabolism in female weanling and retired breeder (RB) rats fed low levels of Ca. Bone mineral density (BMD), bone mineral content (BMC), bone growth parameters, and biochemical markers of bone metabolism were measured. Young rats fed SP had significantly smaller reductions in BMD and BMC after consuming a low Ca diet compared to a casein-based diet. Isoflavones had no further benefits. BMD, BMC and bone growth parameters of RB rats were unaffected by SP. However, SP showed positive effects on bone turnover in both young and RB rats as determined by bone resorption markers. Feeding SP positively affects bone metabolism and minimizes, but does not fully reverse, the negative effects associated with low Ca intakes in young rats. These data merit further investigation on the effects of SP on bone growth, especially when Ca intake is inadequate. (Support: Bureau of Nutritional Sciences, Health Canada)." @default.
- W59646629 created "2016-06-24" @default.
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- W59646629 date "2006-03-01" @default.
- W59646629 modified "2023-09-27" @default.
- W59646629 title "Soy protein and its effects on bone metabolism in young and old female rats fed low dietary calcium" @default.
- W59646629 doi "https://doi.org/10.1096/fasebj.20.5.a854-b" @default.
- W59646629 hasPublicationYear "2006" @default.
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