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• W596544059 abstract "Garcinia achachairu (GAC) is a native plant from Bolivia that has been used in folk medicine for the treatment of gastric disorders, rheumatism, inflammation and as a healing. The phytochemical characterization of this plant extract revealed that the benzophenone guttiferone A (GA) is one of its major compounds, which according to recent studies, has important antioxidant and antimicrobial activity. Considering the interest in deepening the analysis of the pharmacological potential of GA and the lack of studies assessing its genetic toxicity, the present study was designed in order to investigate the genotoxic and mutagenic effects of GA in different cells of mice in vivo, using some of the traditional tests in the mutagenesis area, the Comet Assay (CA) for genotoxicity evaluation and the Micronucleus Test (MT) for the mutagenicity assessment. The experiment was conducted in Swiss albino male mice (Mus musculus) with 12 weeks, divided into five groups with six animals each. The negative control group received, by oral gavage, 0.3 mL of 1% DMSO. The positive control group received, intraperitoneally, 80 mg/Kg of doxorubicin. The treated groups received 0.3 ml of GA at 15, 30 and 60 mg/kg, by gavage. For the genotoxicity evaluation, blood was collected from the tail vein of the mice (4 and 24 hours after treatment), and liver, bone marrow, brain and testicular cells were collected 24 hours after treatment. For the mutagenicity assessment, bone marrow cells were collected 24 hours after treatment. Cytotoxicity was assessed by scoring 200 consecutive polychromatic (PCE) and normochromatic (NCE) erythrocytes and their ratio (PCE/NCE) determined. For the 4 h blood sample, the results with GA at doses of 30 and 60 mg/kg showed that was a statistically significant increase in DNA damage in comparison to the negative control. For the 24 h blood sample, only 60 mg/kg dose showed significant genotoxicity. The analysis of other cell types, with this same test, showed that the three different doses tested induced a statistically significant increase in DNA damage compared to the negative control. By micronucleus test, the results showed that all tested doses of GA no caused change in the polychromatic and normochromatic erythrocytes ratio, indicating absence of cytotoxicity. However, the mutagenicity assessment of GA by the MN test showed that all three doses of the benzophenone tested caused a significant increase of micronucleated polychromatic erythrocytes in the bone marrow cells of animals, showing an clastogenic/aneugenic effect. Given our results and the experimental conditions, we concluded that GA showed genotoxic and clastogenic/aneugenic effects in different cells of mice, which recommends caution in its use by humans, considering the genotoxicity observed and their relationship with the carcinogenesis process." @default.
• W596544059 created "2016-06-24" @default.
• W596544059 creator A5068651133 @default.
• W596544059 date "2013-07-19" @default.
• W596544059 modified "2023-09-23" @default.
• W596544059 title "Estudo do potencial genotóxico da Gutiferona A em diferentes células de camundongos in vitro" @default.
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