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- W59654474 abstract "The model system, Caenorhabditis elegans , was used to study the beneficial effects of green tea extract and of EGCG, one of the main tea polyphenols. EGCG is a strong anti-oxidant in vitro and in vivo and can mediate stress tolerance in C. elegans , treated with the pro-oxidant juglone. The expression of heat shock genes can be down-regulated by EGCG. EGCG reduces the accumulation of lipofuscin, a pigment that increases with age. Furthermore, EGCG can prolong lifespan between 10 and 20%. In transgenic worms, which express Aβ proteins relevant in Alzheimer’s disease, EGCG reduces the formation of Aβ plaques and Aβ oligomerization. A literature review indicates that other food or medicinal plants rich in polyphenols and other anti-oxidants can also support longevity in C. elegans ." @default.
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- W59654474 date "2013-01-01" @default.
- W59654474 modified "2023-10-16" @default.
- W59654474 title "Epigallocatechin Gallate (EGCG) from Green Tea (Camellia sinensis) and Other Natural Products Mediate Stress Resistance and Slows Down Aging Processes in Caenorhabditis elegans" @default.
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- W59654474 doi "https://doi.org/10.1016/b978-0-12-384937-3.00093-8" @default.
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