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- W596642207 abstract "Ischaemia of the liver followed by reperfusion results in endothelial andparenchymal injury through a complex cascade of events. This often occurs inhuman liver transplantation as well as with major liver resections and is referredto as Ischaemia Reperfusion (IR) Injury. Bucillamine is a low molecular weightthiol antioxidant that is capable of rapidly entering cells.This thesis evaluates the effect of Bucillamine on both the early and late phasesof liver warm IR injury with the hypothesis that beneficial effects are inducedcould be due to its action as a free radical scavenger. The drug was evaluated inan in vivo lobar liver ischemia reperfusion model as previously described. MaleSprague –Dawley rats were subjected to 45 mins of partial hepatic (70 %)ischaemia followed by 3 hrs of reperfusion to investigate the early phase ofhepatic IR and 24 hrs of reperfusion to study the late phase of hepatic IR.Changes to the microcirculation, leucocyte adherence and apoptosis wereassessed by intra-vital microscopy. Hepatocellular injury was assessed bystandard liver function tests. Expression of pro and antiapoptotic geneexpression was studied by RT-PCR. Oxidative stress was assessed bymeasuring plasma and hepatic F2 isoprostane levels and tissue glutathionelevels. Cytokine response was assessed by measuring serum CINC-1 levels.Bucillamine improved liver sinusoidal perfusion, reduced leukocyte adherenceand apoptosis in both the early and late phases of IR injury. Hepatocellular injury was reduced. There was no difference in the level of tissue glutathione or tissueand plasma F2 isoprostane levels.This study shows that the hepato protective effect of Bucillamine in warm Liverischemia reperfusion injury is not by direct replenishment of Glutathione level;however, it is through decreased neutrophil activation and recruitment. A clinicaltrial could hence be undertaken in the future to study its efficacy." @default.
- W596642207 created "2016-06-24" @default.
- W596642207 creator A5004251963 @default.
- W596642207 date "2010-05-28" @default.
- W596642207 modified "2023-09-23" @default.
- W596642207 title "Study of the effect of Bucillamine on the early and late phase of hepatic ischaemia reperfusion injury." @default.
- W596642207 hasPublicationYear "2010" @default.
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