FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W596688417> ?p ?o ?g. }

• W596688417 endingPage "15" @default.
• W596688417 startingPage "8" @default.
• W596688417 abstract "HER2/neu expressing cancers constitute 30% of all breast cancers. Trastuzumab, a monoclonal antibody, is widely used for the treatment of HER2/neu expressing breast cancers. The aim of this study was to conjugate trastuzumab with a bifunctional chelator, cyclic Diethylene triamine-pentaacetic anhydride (cDTPAA) for radiolabeling with Tc-99m to develop a radio-pharmaceutical for assessment of HER2/neu status for treatment planning and response monitoring post trastuzumab treatment. cDTPAA was conjugated to trastuzumab at various molar ratios (10:1–100:1). The conjugates were purified and characterized for the integrity and number of chelator molecules conjugated. Radiolabeling of cDTPAA-trastuzumab conjugates was done with Tc-99 m and labeling parameters were studied. The quality control of the radiolabeled preparation was carried out by radio thin layer chromatography (TLC). Endotoxin estimation and sterility test were performed. Biodistribution studies were carried out at different time intervals (1 h, 6 h and 12 h) post intravenous injections in normal rats. The average number of molecules conjugated varied from 0.75 to 7.5 for the different molar ratios experimented. Maximum radiolabeling yield obtained was 90%. Post purification radiochemical purity was >95%. The biodistribution studies showed high activity in liver, kidney and blood retention up to the period of 12 h." @default.
• W596688417 created "2016-06-24" @default.
• W596688417 creator A5009998252 @default.
• W596688417 creator A5010375245 @default.
• W596688417 creator A5018209951 @default.
• W596688417 creator A5018893210 @default.
• W596688417 creator A5045154697 @default.
• W596688417 creator A5053724034 @default.
• W596688417 date "2015-10-01" @default.
• W596688417 modified "2023-10-14" @default.
• W596688417 title "Development and characterization of DTPA-trastuzumab conjugates for radiolabeling with Tc-99m: A radiopharmaceutical for HER2/neu breast cancer" @default.
• W596688417 cites W1988743717 @default.
• W596688417 cites W2006016180 @default.
• W596688417 cites W2012634121 @default.
• W596688417 cites W2019492358 @default.
• W596688417 cites W2030170617 @default.
• W596688417 cites W2039836987 @default.
• W596688417 cites W2058905033 @default.
• W596688417 cites W2074416225 @default.
• W596688417 cites W2089487481 @default.
• W596688417 cites W2089973951 @default.
• W596688417 cites W2095627442 @default.
• W596688417 cites W2100837269 @default.
• W596688417 cites W2105436256 @default.
• W596688417 cites W2124011708 @default.
• W596688417 cites W2130870133 @default.
• W596688417 cites W2143625772 @default.
• W596688417 cites W2146583638 @default.
• W596688417 cites W2163859985 @default.
• W596688417 doi "https://doi.org/10.1016/j.jddst.2015.05.014" @default.
• W596688417 hasPublicationYear "2015" @default.
• W596688417 type Work @default.
• W596688417 sameAs 596688417 @default.
• W596688417 citedByCount "2" @default.
• W596688417 countsByYear W5966884172016 @default.
• W596688417 countsByYear W5966884172022 @default.
• W596688417 crossrefType "journal-article" @default.
• W596688417 hasAuthorship W596688417A5009998252 @default.
• W596688417 hasAuthorship W596688417A5010375245 @default.
• W596688417 hasAuthorship W596688417A5018209951 @default.
• W596688417 hasAuthorship W596688417A5018893210 @default.
• W596688417 hasAuthorship W596688417A5045154697 @default.
• W596688417 hasAuthorship W596688417A5053724034 @default.
• W596688417 hasConcept C112613896 @default.
• W596688417 hasConcept C121608353 @default.
• W596688417 hasConcept C126322002 @default.
• W596688417 hasConcept C134306372 @default.
• W596688417 hasConcept C159654299 @default.
• W596688417 hasConcept C178790620 @default.
• W596688417 hasConcept C185592680 @default.
• W596688417 hasConcept C197336794 @default.
• W596688417 hasConcept C197404232 @default.
• W596688417 hasConcept C202751555 @default.
• W596688417 hasConcept C203014093 @default.
• W596688417 hasConcept C2776872082 @default.
• W596688417 hasConcept C2777807558 @default.
• W596688417 hasConcept C2779786085 @default.
• W596688417 hasConcept C33923547 @default.
• W596688417 hasConcept C521977710 @default.
• W596688417 hasConcept C530470458 @default.
• W596688417 hasConcept C542903549 @default.
• W596688417 hasConcept C55493867 @default.
• W596688417 hasConcept C71924100 @default.
• W596688417 hasConceptScore W596688417C112613896 @default.
• W596688417 hasConceptScore W596688417C121608353 @default.
• W596688417 hasConceptScore W596688417C126322002 @default.
• W596688417 hasConceptScore W596688417C134306372 @default.
• W596688417 hasConceptScore W596688417C159654299 @default.
• W596688417 hasConceptScore W596688417C178790620 @default.
• W596688417 hasConceptScore W596688417C185592680 @default.
• W596688417 hasConceptScore W596688417C197336794 @default.
• W596688417 hasConceptScore W596688417C197404232 @default.
• W596688417 hasConceptScore W596688417C202751555 @default.
• W596688417 hasConceptScore W596688417C203014093 @default.
• W596688417 hasConceptScore W596688417C2776872082 @default.
• W596688417 hasConceptScore W596688417C2777807558 @default.
• W596688417 hasConceptScore W596688417C2779786085 @default.
• W596688417 hasConceptScore W596688417C33923547 @default.
• W596688417 hasConceptScore W596688417C521977710 @default.
• W596688417 hasConceptScore W596688417C530470458 @default.
• W596688417 hasConceptScore W596688417C542903549 @default.
• W596688417 hasConceptScore W596688417C55493867 @default.
• W596688417 hasConceptScore W596688417C71924100 @default.
• W596688417 hasLocation W5966884171 @default.
• W596688417 hasOpenAccess W596688417 @default.
• W596688417 hasPrimaryLocation W5966884171 @default.
• W596688417 hasRelatedWork W1999901958 @default.
• W596688417 hasRelatedWork W2046943494 @default.
• W596688417 hasRelatedWork W2080771324 @default.
• W596688417 hasRelatedWork W2089660886 @default.
• W596688417 hasRelatedWork W2182433122 @default.
• W596688417 hasRelatedWork W2238296306 @default.
• W596688417 hasRelatedWork W2258260565 @default.
• W596688417 hasRelatedWork W2316842651 @default.
• W596688417 hasRelatedWork W2335356348 @default.
• W596688417 hasRelatedWork W2363271996 @default.
• W596688417 hasVolume "29" @default.
• W596688417 isParatext "false" @default.

• next