Matches in SemOpenAlex for { <https://semopenalex.org/work/W59756281> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W59756281 endingPage "9" @default.
- W59756281 startingPage "725" @default.
- W59756281 abstract "To explore action mechanism of electroacupuncture (EA) on treatment and prevention of Parkinson's disease (PD).Fifty clean-grade SD rats were randomly divided into a normal group, a control group, a model group, a pretreatment group and a treatment group, ten rats in each one. The PD model was established by subcutaneous injection of rotenone in neck-back skin (2 mg/kg, dissolved in sun-flower oil, 2 mg/mL in density). The equal-volume sun-flower oil that didn't include rotenone was applied in the control group at the same area as the model group. EA was applied in the treatment group at Fengfu (GV 16) and Taichong (LR 3) with interrupted wave, 2 Hz in frequency, 1 mA in density, for 20 min. The treatment was given once day for conti-nuous 28 days. Rats in the pretreatment group received the same EA as the treatment group for 7 days, and then put into model establishment. After the model establishment, the rats received no treatment and were sacrificed after 28 days. No EA was given in the normal group, model group and control group. The ethology changes were observed and scored. The expression of Parkin, ubiquitin C terminal hydrolase-L1 (UCH-L1) and ubiquitin activating enzyme-1 (UBE1) in substantia nigra was tested by Western-blot method. The positive cell numbers of alpha-synuclein, ubiquitin (UB) and tyrosine hydroxylase (TH) in substantia nigra was tested by immunohistochemical method.There were abnormal ethology manifestation such as yellow and coarse hair, arched back, weaken behavior of resisting arrest and slow movement, which was more relieved in the treatment group and pretreatment group. Compared with normal group and control group, the expression of Parkin, UCH-L1, UBE1, UB, TH in the model group was obviously decreased while alpha-synuclein was obviously increased (all P<0.01). After EA or pretreatment, the expression of Parkin, UCH-L1, UBE1, UB, TH in the treatment group and pretreatment group was higher than that in the model group while expression of alpha-synuclein in the treatment group and pretreatment group was lower than that in the model group (all P<0.01).EA or pretreatment could not only have protective effect for rats with PD, but also increase function of ubiquitin-proteasome system, indicating action mechanism of EA on treatment and prevention of PD may be related with ubiquitin-proteasome system." @default.
- W59756281 created "2016-06-24" @default.
- W59756281 creator A5002092179 @default.
- W59756281 creator A5025185954 @default.
- W59756281 creator A5029569946 @default.
- W59756281 creator A5032716699 @default.
- W59756281 creator A5033429089 @default.
- W59756281 creator A5068046051 @default.
- W59756281 date "2013-08-01" @default.
- W59756281 modified "2023-10-07" @default.
- W59756281 title "[Impacts of electroacupuncture on ubiquitin-proteasome system in rats with Parkinson's disease]." @default.
- W59756281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24195216" @default.
- W59756281 hasPublicationYear "2013" @default.
- W59756281 type Work @default.
- W59756281 sameAs 59756281 @default.
- W59756281 citedByCount "4" @default.
- W59756281 countsByYear W597562812015 @default.
- W59756281 countsByYear W597562812016 @default.
- W59756281 countsByYear W597562812018 @default.
- W59756281 countsByYear W597562812021 @default.
- W59756281 crossrefType "journal-article" @default.
- W59756281 hasAuthorship W59756281A5002092179 @default.
- W59756281 hasAuthorship W59756281A5025185954 @default.
- W59756281 hasAuthorship W59756281A5029569946 @default.
- W59756281 hasAuthorship W59756281A5032716699 @default.
- W59756281 hasAuthorship W59756281A5033429089 @default.
- W59756281 hasAuthorship W59756281A5068046051 @default.
- W59756281 hasConcept C104317684 @default.
- W59756281 hasConcept C126322002 @default.
- W59756281 hasConcept C134018914 @default.
- W59756281 hasConcept C137183658 @default.
- W59756281 hasConcept C142724271 @default.
- W59756281 hasConcept C159167319 @default.
- W59756281 hasConcept C204232928 @default.
- W59756281 hasConcept C204787440 @default.
- W59756281 hasConcept C2776202274 @default.
- W59756281 hasConcept C2776415932 @default.
- W59756281 hasConcept C2778389096 @default.
- W59756281 hasConcept C2779134260 @default.
- W59756281 hasConcept C2779734285 @default.
- W59756281 hasConcept C2780938664 @default.
- W59756281 hasConcept C28859421 @default.
- W59756281 hasConcept C513476851 @default.
- W59756281 hasConcept C55493867 @default.
- W59756281 hasConcept C56837625 @default.
- W59756281 hasConcept C71924100 @default.
- W59756281 hasConcept C86803240 @default.
- W59756281 hasConceptScore W59756281C104317684 @default.
- W59756281 hasConceptScore W59756281C126322002 @default.
- W59756281 hasConceptScore W59756281C134018914 @default.
- W59756281 hasConceptScore W59756281C137183658 @default.
- W59756281 hasConceptScore W59756281C142724271 @default.
- W59756281 hasConceptScore W59756281C159167319 @default.
- W59756281 hasConceptScore W59756281C204232928 @default.
- W59756281 hasConceptScore W59756281C204787440 @default.
- W59756281 hasConceptScore W59756281C2776202274 @default.
- W59756281 hasConceptScore W59756281C2776415932 @default.
- W59756281 hasConceptScore W59756281C2778389096 @default.
- W59756281 hasConceptScore W59756281C2779134260 @default.
- W59756281 hasConceptScore W59756281C2779734285 @default.
- W59756281 hasConceptScore W59756281C2780938664 @default.
- W59756281 hasConceptScore W59756281C28859421 @default.
- W59756281 hasConceptScore W59756281C513476851 @default.
- W59756281 hasConceptScore W59756281C55493867 @default.
- W59756281 hasConceptScore W59756281C56837625 @default.
- W59756281 hasConceptScore W59756281C71924100 @default.
- W59756281 hasConceptScore W59756281C86803240 @default.
- W59756281 hasIssue "8" @default.
- W59756281 hasLocation W597562811 @default.
- W59756281 hasOpenAccess W59756281 @default.
- W59756281 hasPrimaryLocation W597562811 @default.
- W59756281 hasRelatedWork W2366788704 @default.
- W59756281 hasRelatedWork W2370232633 @default.
- W59756281 hasRelatedWork W2377321435 @default.
- W59756281 hasRelatedWork W2377899948 @default.
- W59756281 hasRelatedWork W2387124707 @default.
- W59756281 hasRelatedWork W2404720739 @default.
- W59756281 hasRelatedWork W2961144956 @default.
- W59756281 hasRelatedWork W3030786903 @default.
- W59756281 hasRelatedWork W4200140506 @default.
- W59756281 hasRelatedWork W4282925286 @default.
- W59756281 hasVolume "33" @default.
- W59756281 isParatext "false" @default.
- W59756281 isRetracted "false" @default.
- W59756281 magId "59756281" @default.
- W59756281 workType "article" @default.