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- W597898136 abstract "Objective To investigate the effect of mifepristone on the function of transforming growth factor β signal transduction in chorionic villi and the molecular mechanism of mifepristone inducing abortion.Methods Early pregnant chorionic villi were obtained from the surgical aspiration group(n=13) and the mifepristone inducing abortion group(n=20).Expression of smad7 which was the targeting gene of the TGF-β/smads signal transduction pathway in chorionic villi was determined by immunohistochemical staining with specific antibody and RT-PCR.Mean optic density and density scale were anzlyzed.Results Mean optic density of Smad7 in chorionic villi in the mifepristone inducing abortion group(0.346?6±0.046?9) was statistically higher than that in the surgical aspiration group(0.233?7±0.065?7)(P0.01).Also,density scale of smad7mRNA in chorionic villi in the mifepristone inducing abortion group(0.561?7±0.410?3) was statistically higher than that in the surgical aspiration group(0.222?2±0.244?1)(P0.02). Conclusion Mifepristone can up-regulate the function of the TGF-β/smads signal transduction pathway and expression of targeted genes,such as plasminogen activator inhibitor 1,affect migration and evasion of tropholast cells,which may be one of the molecular mechanisms for termination of early pregnancy by this drug." @default.
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- W597898136 date "2009-01-01" @default.
- W597898136 modified "2023-09-23" @default.
- W597898136 title "Mifepristone modulates the function of TGF-β/smads signal transduction pathway in early pregnant chorionic villi." @default.
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