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- W59790868 abstract "Publisher Summary This chapter focuses the way rabies and pseudorabies viruses (PrV) attach, enter, and propagate themselves in neurons. It also examines mutants of these viruses with modified neurotropism. The use of these two types of viruses as tracers for neuronal network or as vectors for gene therapy in the central nervous system and the general features of the molecular biology of rabies and pseudorabies viruses are also discussion… Rabies is a negative single-stranded, unsegmented RNA virus with an enveloped bullet-shape virion composed of five different proteins. Rabies virus infects a variety of mammals, but rodents have become the standard laboratory animals that are used to study the properties of this virus. Rabies has a similar replication cycle in neurons as has been found in cells maintained in culture, but the morphology of the neuron with its extended axonal and dendritic processes imposes some differences. The chapter describes direct penetration and propagation of rabies and PrV into peripheral neurons. Rabies and PrV can enter neurons directly without prior replication in local nonneural tissues. Viral infection spreads in a transneuronal fashion to infect most categories of neurons that synapse on first-order infected neurons. In the case of rabies virus, second-order neurons in trigeminal sensory nuclei are refractory to infection, at least after intraocular inoculation. Neurotropic viruses are potential tools for genetic manipulation of the nervous system. The rabies genome, like other no segmented RNA genomes, is not infectious. The RNA molecule needs to be adequately wrapped into the nucleocapsid protein and transcribed by two viral proteins, P and L, in order to initiate an infectious cycle. The chapter also illustrates the infection of glial cells and determines specific receptors for rabies and PrV." @default.
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- W59790868 date "1995-01-01" @default.
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- W59790868 title "Molecular Analysis of Rabies and Pseudorabies Neurotropism" @default.
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- W59790868 doi "https://doi.org/10.1016/b978-012397570-6/50023-x" @default.
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