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• W598437543 abstract "A newly developed epifluorescense microscopy system has been employed to measure net transepithelial secretion of fluorescein (FL) in real time in isolated perfused S2 segments of rabbit renal proximal tubules. Net FL secretion (K„ ~A |j.M, and ~280 fmol min ' tnm ') shares the same transport system with that of paraaminohippurate (PAH). The basolateral Na-DC cotransporter supports ~25% of the basal FL secretion in the absence of exogenous aKG via recycling of aKG that has been exchanged for FL. Physiological aKG concentrations in the bath (~10 |iM) or in the perfusate (-50 |iM) stimulated net secretion of FL by ~30 or -20%, respectively. These data indicate that the basolateral Na-DC cotransporter supports -42% of the net FL secretion. The luminal and basolateral effects of physiological concentrations of aKG were additive. Together, the basolateral and luminal Na-DC cotransporters can directly support -50% of the net FL secretion, apparently, by their establishing and maintaining the outwardly directed aKG gradient responsible for driving basolateral FL/aKG exchange. The remaining -50% would be maintained by metabolic production of aKG in the cells. Adding of 100 nM phorbol 12-myristate 13-acetate (PMA), a known PKC activator, to the bath decreased steady-state secretion of FL by -30% after 25 min incubation. This inhibition was irreversible and mcreased to -60% 25 min following removal of PMA. The inhibition produced by PMA was blocked when 100 nM of either staurosporine (ST) or bisindolylmaleimide I (BIM), both known PKC inhibitors, was" @default.
• W598437543 created "2016-06-24" @default.
• W598437543 creator A5083332939 @default.
• W598437543 date "1999-01-01" @default.
• W598437543 modified "2023-09-23" @default.
• W598437543 title "Real-time assessment of organic anion secretion in isolated, perfused rabbit renal proximal tubules" @default.
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