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- W59857517 abstract "Abstract Over recent years, the availability of whole-genome sequences for multiple, diverse eukaryotes has allowed unprecedented analysis of the evolution of dyneins. The power of many analyses lies in the ability to delineate full repertoires of dynein subunits and proteins with associated functions. In combination with improved analysis methods, this has revealed a richer evolutionary history and greater diversity to dyneins than was initially expected. Phylogenetic analyses show a clear consensus for nine major dynein heavy chain (DHC) families, eight of which are associated with ciliary/flagellar functions. Current data suggest that possible additional types of DHC with very limited taxonomic distribution represent divergent or incorrectly assembled copies from established families rather than new ancestral classes. All nine DHC families existed in the last eukaryotic common ancestor and are widely distributed amongst extant species. However, during the radiation of eukaryotes all families experienced multiple losses, with the result that no family is now ubiquitous and at least three eukaryotic lineages entirely lack dynein motors. Rooting of DHC phylogenies has significant consequences for the likely evolutionary path by which the cilium formed, and reconciling trees and cell biological data suggests a plausible path for the stepwise evolution of the dynein families in the proto-eukaryotic cell. Reconstructing the evolution of the first dynein from its prokaryotic origin is still very challenging, but the identification of the closest extant relatives of DHCs tentatively suggests descent from a complex with chaperone-like activity." @default.
- W59857517 created "2016-06-24" @default.
- W59857517 creator A5027929813 @default.
- W59857517 creator A5085124376 @default.
- W59857517 date "2012-01-01" @default.
- W59857517 modified "2023-09-24" @default.
- W59857517 title "Evolutionary Biology of Dyneins" @default.
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