Matches in SemOpenAlex for { <https://semopenalex.org/work/W59892476> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W59892476 abstract "SIRT6 is a site-specific histonedeacetylase of H3K9Ac and H3K56Ac, with various roles in DNA repair, telomere maintenance, energy metabolism, and the target gene expression mediated by transcription factors NF-kappaB, HIF1alpha and PARP1. However, these studies were mostly performed in normal cells, while the roles of SIRT6 in cancers remained undetermined. From deposited large scale gene profiling studies, we identified that SIRT6 was highly expressed in metastatic prostate tumor, compared with normal or paratumor prostate tissue or even primary prostate tumor. We then hypothesized that upregulation of SIRT6 might promote prostate tumor development, and we could control prostate cancer through SIRT6 downregulation. Here we observed the overexpression of SIRT6 both in prostate tumor tissues andprostate cancer cells. We also found that downregulation of SIRT6 in PC-3 human prostate cancer cells led to sub-G1 phase arrest of cell cycle, increased apoptosis, reduced migration ability and downregulation of multiple cancer-related genes, including BCL2, MDR, CDH1, CDH2 and CD44. Moreover, SIRT6-deficiency reduced cell viability and enhanced chemotherapeutics sensitivity. Our findings uncovered some of the SIRT6 functions in prostate cancer, and might provide a new approach on prostate cancer therapy." @default.
- W59892476 created "2016-06-24" @default.
- W59892476 creator A5008008825 @default.
- W59892476 creator A5025547618 @default.
- W59892476 creator A5036365256 @default.
- W59892476 creator A5048925301 @default.
- W59892476 creator A5061972961 @default.
- W59892476 creator A5062047914 @default.
- W59892476 creator A5087784661 @default.
- W59892476 date "2012-04-01" @default.
- W59892476 modified "2023-10-18" @default.
- W59892476 title "Inhibition of the overexpressing SIRT6 sensitizes prostate cancer cells to chemotherapeutics" @default.
- W59892476 doi "https://doi.org/10.1096/fasebj.26.1_supplement.lb521" @default.
- W59892476 hasPublicationYear "2012" @default.
- W59892476 type Work @default.
- W59892476 sameAs 59892476 @default.
- W59892476 citedByCount "0" @default.
- W59892476 crossrefType "journal-article" @default.
- W59892476 hasAuthorship W59892476A5008008825 @default.
- W59892476 hasAuthorship W59892476A5025547618 @default.
- W59892476 hasAuthorship W59892476A5036365256 @default.
- W59892476 hasAuthorship W59892476A5048925301 @default.
- W59892476 hasAuthorship W59892476A5061972961 @default.
- W59892476 hasAuthorship W59892476A5062047914 @default.
- W59892476 hasAuthorship W59892476A5087784661 @default.
- W59892476 hasConcept C104317684 @default.
- W59892476 hasConcept C119157956 @default.
- W59892476 hasConcept C121608353 @default.
- W59892476 hasConcept C126322002 @default.
- W59892476 hasConcept C127561419 @default.
- W59892476 hasConcept C2776235491 @default.
- W59892476 hasConcept C2777595374 @default.
- W59892476 hasConcept C2780192828 @default.
- W59892476 hasConcept C2780561631 @default.
- W59892476 hasConcept C29537977 @default.
- W59892476 hasConcept C502942594 @default.
- W59892476 hasConcept C55493867 @default.
- W59892476 hasConcept C71924100 @default.
- W59892476 hasConcept C86803240 @default.
- W59892476 hasConceptScore W59892476C104317684 @default.
- W59892476 hasConceptScore W59892476C119157956 @default.
- W59892476 hasConceptScore W59892476C121608353 @default.
- W59892476 hasConceptScore W59892476C126322002 @default.
- W59892476 hasConceptScore W59892476C127561419 @default.
- W59892476 hasConceptScore W59892476C2776235491 @default.
- W59892476 hasConceptScore W59892476C2777595374 @default.
- W59892476 hasConceptScore W59892476C2780192828 @default.
- W59892476 hasConceptScore W59892476C2780561631 @default.
- W59892476 hasConceptScore W59892476C29537977 @default.
- W59892476 hasConceptScore W59892476C502942594 @default.
- W59892476 hasConceptScore W59892476C55493867 @default.
- W59892476 hasConceptScore W59892476C71924100 @default.
- W59892476 hasConceptScore W59892476C86803240 @default.
- W59892476 hasIssue "S1" @default.
- W59892476 hasLocation W598924761 @default.
- W59892476 hasOpenAccess W59892476 @default.
- W59892476 hasPrimaryLocation W598924761 @default.
- W59892476 hasRelatedWork W1980245127 @default.
- W59892476 hasRelatedWork W2106003470 @default.
- W59892476 hasRelatedWork W2227031353 @default.
- W59892476 hasRelatedWork W2400504790 @default.
- W59892476 hasRelatedWork W2429027331 @default.
- W59892476 hasRelatedWork W2433835599 @default.
- W59892476 hasRelatedWork W2601368393 @default.
- W59892476 hasRelatedWork W3155718207 @default.
- W59892476 hasRelatedWork W3195749948 @default.
- W59892476 hasRelatedWork W4362495310 @default.
- W59892476 hasVolume "26" @default.
- W59892476 isParatext "false" @default.
- W59892476 isRetracted "false" @default.
- W59892476 magId "59892476" @default.
- W59892476 workType "article" @default.