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- W599179214 abstract "The observation of Miller [1] that single-strand breaks in DNA stimulate poly(ADP-ribose) synthetase has led to a large amount of research exploring a possible role for this enzyme in DNA repair [2]. Inhibitors of the enzyme have been shown to enhance the cytotoxicity of DNA damaging agents [3]. The majority of work has focussed on monofunctional alkylating agents in conjunction with inhibitors of poly(ADP-ribose) synthetase, but because this class of compounds has extremely little clinical use we have explored the interaction of the inhibitor 3-acetoamidobenzamide (3AAB) with the glycopeptide antibiotic, bleomycin (BLM), or with the bifunctional alkylating agent, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Both of these drugs are widely used in cancer chemotherapy, either singly or in combination with other treatments." @default.
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- W599179214 date "1985-01-01" @default.
- W599179214 modified "2023-09-28" @default.
- W599179214 title "Potentiation of the Effects of Bleomycin and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea on A549 Cell Cultures by Inhibitors of Poly(ADP-Ribose) Synthetase" @default.
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- W599179214 doi "https://doi.org/10.1007/978-3-642-70589-2_43" @default.
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