Matches in SemOpenAlex for { <https://semopenalex.org/work/W59953275> ?p ?o ?g. }
- W59953275 endingPage "203" @default.
- W59953275 startingPage "187" @default.
- W59953275 abstract "The biosynthesis, biodistribution, and physiological consequences of carbon monoxide (CO) in humans are intimately linked to the utilization of the heme molecule in vital cellular processes. CO, though chemically inert, acts as a heme iron ligand. Living organisms acquire CO by inhalation, by endogenous enzymatic heme degradation catalyzed by heme oxygenases (HOs), or as a byproduct of lipid and xenobiotic metabolism. The HO enzymes exist in both constitutive (HO-2, HO-3) and inducible (HO-1) isoforms, the latter classified as a mammalian stress protein involved in cellular defense. HO quantitatively converts heme to CO, biliverdin, and iron, and these metabolites may all participate in HO-mediated cytoprotection. Although extremely toxic at elevated concentrations, CO may exert anti-inflammatory and anti-apoptotic properties at low concentrations. Endogenously produced CO is redistributed throughout the body as carboxyhemoglobin and excreted through the lungs by diffusion. Possible medical applications for CO include its therapeutic delivery as an anti-inflammatory agent, and its measurement in exhaled breath as a general biomarker of inflammatory states." @default.
- W59953275 created "2016-06-24" @default.
- W59953275 creator A5028298831 @default.
- W59953275 creator A5068367251 @default.
- W59953275 date "2004-01-01" @default.
- W59953275 modified "2023-09-23" @default.
- W59953275 title "Synthesis and Metabolism of Carbon Monoxide" @default.
- W59953275 cites W11773850 @default.
- W59953275 cites W1263203087 @default.
- W59953275 cites W143216615 @default.
- W59953275 cites W1500284214 @default.
- W59953275 cites W1551093971 @default.
- W59953275 cites W1561810071 @default.
- W59953275 cites W1595202381 @default.
- W59953275 cites W1597487419 @default.
- W59953275 cites W1600690434 @default.
- W59953275 cites W1655162787 @default.
- W59953275 cites W1880542775 @default.
- W59953275 cites W1898100628 @default.
- W59953275 cites W1945340136 @default.
- W59953275 cites W1963676888 @default.
- W59953275 cites W1966181260 @default.
- W59953275 cites W1966557915 @default.
- W59953275 cites W1966582616 @default.
- W59953275 cites W1966973099 @default.
- W59953275 cites W1967579132 @default.
- W59953275 cites W1967618975 @default.
- W59953275 cites W1968301638 @default.
- W59953275 cites W1972442898 @default.
- W59953275 cites W1973081785 @default.
- W59953275 cites W1973482230 @default.
- W59953275 cites W1973900216 @default.
- W59953275 cites W1974371318 @default.
- W59953275 cites W1978098707 @default.
- W59953275 cites W1978719611 @default.
- W59953275 cites W1980727463 @default.
- W59953275 cites W1981559163 @default.
- W59953275 cites W1981960187 @default.
- W59953275 cites W1984775683 @default.
- W59953275 cites W1985289402 @default.
- W59953275 cites W1985863048 @default.
- W59953275 cites W1986525923 @default.
- W59953275 cites W1987777210 @default.
- W59953275 cites W1988205788 @default.
- W59953275 cites W1988214905 @default.
- W59953275 cites W1988778347 @default.
- W59953275 cites W1988787425 @default.
- W59953275 cites W1993596487 @default.
- W59953275 cites W1993808439 @default.
- W59953275 cites W1994251846 @default.
- W59953275 cites W1994561091 @default.
- W59953275 cites W1995726976 @default.
- W59953275 cites W1997661663 @default.
- W59953275 cites W1998722744 @default.
- W59953275 cites W1999554896 @default.
- W59953275 cites W2000254823 @default.
- W59953275 cites W2001411803 @default.
- W59953275 cites W2001727816 @default.
- W59953275 cites W2006358233 @default.
- W59953275 cites W2012113452 @default.
- W59953275 cites W2012411332 @default.
- W59953275 cites W2012455499 @default.
- W59953275 cites W2013790946 @default.
- W59953275 cites W2015458277 @default.
- W59953275 cites W2018058963 @default.
- W59953275 cites W2019003542 @default.
- W59953275 cites W2019539179 @default.
- W59953275 cites W2020294980 @default.
- W59953275 cites W2022693510 @default.
- W59953275 cites W2022860822 @default.
- W59953275 cites W2028778467 @default.
- W59953275 cites W2029276286 @default.
- W59953275 cites W2030365747 @default.
- W59953275 cites W2032731524 @default.
- W59953275 cites W2033158271 @default.
- W59953275 cites W2036391083 @default.
- W59953275 cites W2039679742 @default.
- W59953275 cites W2040672611 @default.
- W59953275 cites W2041553103 @default.
- W59953275 cites W2041710080 @default.
- W59953275 cites W2044953143 @default.
- W59953275 cites W2051105332 @default.
- W59953275 cites W2055297375 @default.
- W59953275 cites W2055655700 @default.
- W59953275 cites W2056523101 @default.
- W59953275 cites W2058095457 @default.
- W59953275 cites W2061762822 @default.
- W59953275 cites W2062589077 @default.
- W59953275 cites W2063286759 @default.
- W59953275 cites W2066033513 @default.
- W59953275 cites W2067896742 @default.
- W59953275 cites W2069420389 @default.
- W59953275 cites W2072594844 @default.
- W59953275 cites W2078504703 @default.
- W59953275 cites W2081134982 @default.
- W59953275 cites W2081347741 @default.
- W59953275 cites W2081635255 @default.
- W59953275 cites W2082245404 @default.