FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W599827145> ?p ?o ?g. }

• W599827145 endingPage "290" @default.
• W599827145 startingPage "281" @default.
• W599827145 abstract "Background The purpose of the study was to characterize the rare cohort of patients (pts) with metastatic colorectal cancer (mCRC) and brain metastasis (BM) and to identify prognostic subgroups. Patients and Methods In collaboration with the Munich Cancer Registry, pts with mCRC and BM who were diagnosed between 1998 and 2011 were identified. Survival from the time of first diagnosis of colorectal cancer (CRC) (OS-1), from the time of diagnosis of metastatic disease (OS-2) and of BM (OS-3) was calculated regarding (1) the temporal occurrence of extra- and intracranial metastasis (meta- vs. synchronous) and (2) tumor and patient characteristics. For survival analysis the Kaplan–Meier estimator and Cox regression models were used. Results A total of 228 pts (134 male [59%], 94 female [41%]) were identified. The median age was 63 years (142 pts [62%] were 65 years of age or younger). Most pts presented with primary tumors staged T3/4, N+, Grade 2. The primary tumor was located predominantly in the left colon (155 pts; 68%), especially in the rectum (95 pts; 42%). Median OS-1 was 35.6 months (95% confidence interval [CI], 30.1-41.1 months), OS-2 was 16.5 months (95% CI, 13.9-19.1 months), and OS-3 was 2.0 months (95% CI, 1.5-2.5 months). Median time from first CRC diagnosis to BM was 29.2 months. Subsequent BM after extracranial metastasis were observed in 184 pts (80.7%), whereas 31 pts (13.6%) presented with solitary BM. Univariate analysis did not reveal a prognostic variable for overall survival after diagnosis of BM. Conclusion This study presents the largest number of pts with mCRC and BM analyzed to date. The results show that most mCRC pts develop BM as a late step in the course of disease. Median time from first CRC diagnosis to BM is 29.2 months. Only a few pts were diagnosed with BM early in the disease or with solitary BM. When BM is present survival is poor." @default.
• W599827145 created "2016-06-24" @default.
• W599827145 creator A5003959469 @default.
• W599827145 creator A5011137037 @default.
• W599827145 creator A5031667128 @default.
• W599827145 creator A5034205085 @default.
• W599827145 creator A5037754184 @default.
• W599827145 creator A5038403890 @default.
• W599827145 creator A5038858206 @default.
• W599827145 creator A5046167545 @default.
• W599827145 creator A5050316905 @default.
• W599827145 creator A5065388874 @default.
• W599827145 creator A5067922941 @default.
• W599827145 creator A5068993095 @default.
• W599827145 creator A5069163373 @default.
• W599827145 creator A5069503507 @default.
• W599827145 creator A5069585976 @default.
• W599827145 creator A5085829166 @default.
• W599827145 date "2015-12-01" @default.
• W599827145 modified "2023-09-23" @default.
• W599827145 title "Brain Metastasis in Colorectal Cancer Patients: Survival and Analysis of Prognostic Factors" @default.
• W599827145 cites W1594731676 @default.
• W599827145 cites W1619597457 @default.
• W599827145 cites W1966703018 @default.
• W599827145 cites W2005348280 @default.
• W599827145 cites W2006488415 @default.
• W599827145 cites W2012767846 @default.
• W599827145 cites W2013195627 @default.
• W599827145 cites W2022428794 @default.
• W599827145 cites W2026152461 @default.
• W599827145 cites W2026707626 @default.
• W599827145 cites W2031229122 @default.
• W599827145 cites W2039202448 @default.
• W599827145 cites W2064343154 @default.
• W599827145 cites W2069392276 @default.
• W599827145 cites W2086391612 @default.
• W599827145 cites W2093649059 @default.
• W599827145 cites W2094697691 @default.
• W599827145 cites W2096065464 @default.
• W599827145 cites W2102601309 @default.
• W599827145 cites W2108235590 @default.
• W599827145 cites W2138885918 @default.
• W599827145 cites W2142479365 @default.
• W599827145 cites W2330763029 @default.
• W599827145 cites W2339474338 @default.
• W599827145 cites W2416419971 @default.
• W599827145 cites W2789384250 @default.
• W599827145 doi "https://doi.org/10.1016/j.clcc.2015.05.009" @default.
• W599827145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26123495" @default.
• W599827145 hasPublicationYear "2015" @default.
• W599827145 type Work @default.
• W599827145 sameAs 599827145 @default.
• W599827145 citedByCount "47" @default.
• W599827145 countsByYear W5998271452016 @default.
• W599827145 countsByYear W5998271452017 @default.
• W599827145 countsByYear W5998271452018 @default.
• W599827145 countsByYear W5998271452019 @default.
• W599827145 countsByYear W5998271452020 @default.
• W599827145 countsByYear W5998271452021 @default.
• W599827145 countsByYear W5998271452022 @default.
• W599827145 countsByYear W5998271452023 @default.
• W599827145 crossrefType "journal-article" @default.
• W599827145 hasAuthorship W599827145A5003959469 @default.
• W599827145 hasAuthorship W599827145A5011137037 @default.
• W599827145 hasAuthorship W599827145A5031667128 @default.
• W599827145 hasAuthorship W599827145A5034205085 @default.
• W599827145 hasAuthorship W599827145A5037754184 @default.
• W599827145 hasAuthorship W599827145A5038403890 @default.
• W599827145 hasAuthorship W599827145A5038858206 @default.
• W599827145 hasAuthorship W599827145A5046167545 @default.
• W599827145 hasAuthorship W599827145A5050316905 @default.
• W599827145 hasAuthorship W599827145A5065388874 @default.
• W599827145 hasAuthorship W599827145A5067922941 @default.
• W599827145 hasAuthorship W599827145A5068993095 @default.
• W599827145 hasAuthorship W599827145A5069163373 @default.
• W599827145 hasAuthorship W599827145A5069503507 @default.
• W599827145 hasAuthorship W599827145A5069585976 @default.
• W599827145 hasAuthorship W599827145A5085829166 @default.
• W599827145 hasConcept C121608353 @default.
• W599827145 hasConcept C126322002 @default.
• W599827145 hasConcept C143998085 @default.
• W599827145 hasConcept C144301174 @default.
• W599827145 hasConcept C2778164965 @default.
• W599827145 hasConcept C2778527826 @default.
• W599827145 hasConcept C2779013556 @default.
• W599827145 hasConcept C2780283643 @default.
• W599827145 hasConcept C2781074409 @default.
• W599827145 hasConcept C38180746 @default.
• W599827145 hasConcept C44249647 @default.
• W599827145 hasConcept C50382708 @default.
• W599827145 hasConcept C526805850 @default.
• W599827145 hasConcept C71924100 @default.
• W599827145 hasConcept C72563966 @default.
• W599827145 hasConcept C90924648 @default.
• W599827145 hasConceptScore W599827145C121608353 @default.
• W599827145 hasConceptScore W599827145C126322002 @default.
• W599827145 hasConceptScore W599827145C143998085 @default.
• W599827145 hasConceptScore W599827145C144301174 @default.

• next