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• W60064568 abstract "Moringa oleifera (MO) is reported to have various medicinal properties. The aim ofthis study is to evaluate the hepatoprotective effect of MO leaf extract againstacetaminophen (APAP) induced liver damage in rats. A dose of 3g/kg APAP wasselected to induce liver damage. Seventy male Sprague-Dawley rats (n=70) weredivided into seven groups. Five groups of animals were given various oralpretreatments of 200mg/kg MO, 800mg/kg MO and 200mg/kg Silymarin (Sil) indistilled water at 3ml/day for fourteen days. Meanwhile, two groups served ashepatotoxicity (3g/kgAPAP) and vehicle (40% sucrose) control groups were givendistilled water in the similar manner. On day 15, the animals were challenged with3g/kg APAP in 40% sucrose except for rats in the vehicle (40% sucrose) and MOcontrol groups which received 40% sucrose solution. After 24 and 48 hours bloodwas withdrawn and livers were harvested. Plasma was prepared and liver functionwas carried out to determine levels of alanine aminotransferase (ALT), aspartateaminotransferase (AST) and alkaline phosphatase (ALP). Liver samples were takenfor histopathalogical examination, measurement of hepatic reduced glutathione (GSH) content, glutathione-S-transferase (GST), glutathione peroxidase (GPx) andglutathione reductase (GR) activities as well as determining malondialdehyde(MDA) levels. Statistical analysis was performed using analysis of variance(ANOVA) and Kruskall Wallis analysis of variance coupled with the Mann–WhitneyU-test. APAP treatment caused significant elevation (p<0.05) of ALT, AST after 24and 48 hours. Histopathological observations substantiated these findings showingsignificant (p<0.05) liver damage. APAP treatment caused marked reduction(p<0.05) in hepitic GSH content, GST and GPx. activities coupled with significantincrease (p< 0.05) in lipid peroxidation index. The changes observed weretime dependent with more changes were noted after 48 hours. Significant (p<0.05)elevation of ALP and significant (p<0.05) decline of GR activity was only notedafter 48 hours compared to other groups. 200mg/kg and 800mg/kg MO extractequally showed a significant (p<0.05) amelioration of ALT, AST and ALP levels anda significant reduction (p<0.05) of pathological alteration in a manner similar to Sil.MO extracts showed no signs of toxicity up to a dose level of 800 mg/kg. MO alonesignificantly increased (p<0.05) GSH content and restored GSH level (p<0.05) in thegroups given MO and challenged with APAP. MO alone showed insignificantincrease of GST, Gap and GR activities. The significant increase (p<0.05) of theseantioxidant enzymes observed in groups received MO extracts and challenged withAPAP. Lipid peroxidation was significantly (p<0.05) inhibited by the extracts indose independent manner. A significant (p<0.05) increase of GST activities by200mg/kg and 800mg/kg MO extracts to the level higher than vehicle group wereobserved as early as 24 hours in comparison with rats given pretreatment ofSilymarin. On the other hand, 200 mg/kg MO significantly (p<0.05) showed similarincrease in GPx activity to the level higher than vehicle group in comparison with groups that given 200mg/kg Sil and 800mg/kg MO pretreatment. Prevention ofenzyme leakage, preservation of hepatocytes structural integrity, prevention of GSHdepletion, restoration of antioxidant enzymes activity that is essential in acceleratingdetoxification and excretion of APAP toxic metabolites, as well inhibition of lipidperoxidative processes reveals that the extracts of MO leaves possesses potentialhepatoprotective activity against APAP induced damage in rats." @default.
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• W60064568 date "2007-01-01" @default.
• W60064568 modified "2023-09-26" @default.
• W60064568 title "Hepatoprotective Effect of Moringa Oleifera Leaves Extract on Acetaminophen-Induced Liver Damage in Rats" @default.
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