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• W60085825 abstract "In the last 2 years, there have been several reports of the administration of heterologous antilymphocyte globulin (ALG) to humans. The objectives have varied. In our own institution1–4 and more recently in several others5–9 ALG prepared from immune horse serum has been added to the basic immunosuppressive regimen of azathio-prine and prednisone after the transplantation of vital whole organs including the kidney, liver, and heart. In addition, heterologous antilymphocyte derivitives have been used alone for the purpose of determining what changes in immunologic reactivity were thereby induced in volunteers,10 or in an effort to treat autoimmune diseases8 and lymphatic leukemia.11There is no point in reviewing here the large body of incontrovertible evidence that ALG can slow or prevent the rejection of a variety of homografts in several species of lower animals as well as in subhuman primates. Suffice it to say that ALG also has an easily demonstrable immunosuppressive effect when used as the only treatment in man inasmuch as skin graft survival is prolonged10 and the expression of pre-existing hypersensitivity states is blunted or eliminated.2,5,8,12Equally unchallenged is the fact that there is a significant morbidity with the clinical administration of ALG as most fully described by Kashiwagi13 and mentioned by others as well.5,6,10 The intramuscular injections are almost always painful, often cause fever, may eventually evoke classical foreign protein reactions including anaphylaxis, and can precipitate thrombocytopenic crises. However, lethal complications must be rare. We have treated more than 100 recipients of renal or liver homografts with ALG without a drug-related death.Conceding that the immunosuppressive effect of immune globulin is not doubted in any species including man in which it has been tested, other avenues of inquiry remain open including whether the benefit of ALG is outweighed by its side effects, if there is really a need to add globulin therapy to that with the standard drugs or if this practice will lead to increased survival, how the globulin might be refined and made less toxic, and what improved schedules of administration could be evolved for clinical use. It is upon these issues that this communication will touch." @default.
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• W60085825 date "1969-03-01" @default.
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• W60085825 title "A trial with heterologous antilymphocyte globulin in man." @default.
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